FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term intracellular signal transduction ID (Ontology) GO:0035556 (Gene Ontology)
Definition The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.[ ISBN:3527303782 ]
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Annotations
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Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     129
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 intracellular signal transduction (all annotations which use CV term, excluding "NOT" statements)     129
     involved_in | intracellular signal transduction     129
Spanning Tree (Parents/Children)
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cellular process________________
regulation of cellular process__|
                                signal transduction
                                 |__intracellular signal transduction  785 rec.
                                     |__cell cycle checkpoint signaling 63 rec.
                                     |   |__DNA integrity checkpoint signaling(+) 44 rec.
                                     |   |__meiotic cell cycle checkpoint signaling(+) 4 rec.
                                     |   |__mitotic cell cycle checkpoint signaling(+) 45 rec.
                                     |   |__spindle checkpoint signaling(+) 14 rec.
                                     |__chloroplast-nucleus signaling pathway
                                     |__endoplasmic reticulum unfolded protein response 24 rec.
                                     |   |__ATF6-mediated unfolded protein response
                                     |   |__IRE1-mediated unfolded protein response 4 rec.
                                     |   |__PERK-mediated unfolded protein response 2 rec.
                                     |__ER-nucleus signaling pathway 7 rec.
                                     |   |__ATF6-mediated unfolded protein response
                                     |   |__ER overload response(+)
                                     |   |__PERK-mediated unfolded protein response 2 rec.
                                     |   |__SREBP signaling pathway 5 rec.
                                     |__hippo signaling 101 rec.
                                     |__hypoxia-inducible factor-1alpha signaling pathway
                                     |__intracellular receptor signaling pathway 32 rec.
                                     |   |__blue light signaling pathway 1 rec.
                                     |   |__cytoplasmic pattern recognition receptor signaling pathway(+) 9 rec.
                                     |   |__juvenile hormone mediated signaling pathway 5 rec.
                                     |   |__nuclear receptor-mediated signaling pathway(+) 15 rec.
                                     |__intracellular signaling cassette 428 rec.
                                     |   |__calcium-mediated signaling(+) 34 rec.
                                     |   |__cAMP/PKA signal transduction 8 rec.
                                     |   |__canonical NF-kappaB signal transduction 13 rec.
                                     |   |__integrated stress response signaling(+) 2 rec.
                                     |   |__MAPK cascade(+) 167 rec.
                                     |   |__nitric oxide mediated signal transduction(+) 5 rec.
                                     |   |__non-canonical NF-kappaB signal transduction 3 rec.
                                     |   |__phosphatidylinositol 3-kinase/protein kinase B signal transduction 33 rec.
                                     |   |__phospholipase C/protein kinase C signal transduction
                                     |   |__SMAD protein signal transduction 11 rec.
                                     |   |__small GTPase-mediated signal transduction(+) 194 rec.
                                     |__intrinsic apoptotic signaling pathway 27 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to DNA damage(+) 15 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(+) 7 rec.
                                     |   |__intrinsic apoptotic signaling pathway in response to hypoxia
                                     |   |__intrinsic apoptotic signaling pathway in response to nitrosative stress
                                     |   |__intrinsic apoptotic signaling pathway in response to osmotic stress(+)
                                     |   |__intrinsic apoptotic signaling pathway in response to oxidative stress(+) 2 rec.
                                     |__mitochondria-nucleus signaling pathway
                                     |__osmosensory signaling pathway
                                     |   |__osmosensory signaling pathway via Sho1 osmosensor
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |__phosphatidylinositol-mediated signaling 9 rec.
                                     |__phosphorelay signal transduction system
                                     |   |__ethylene-activated signaling pathway(+)
                                     |   |__osmosensory signaling via phosphorelay pathway
                                     |__protein kinase C signaling 1 rec.
                                     |__RAM/MOR signaling
                                     |__signal transduction by p53 class mediator 11 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator 5 rec.
                                     |   |__intrinsic apoptotic signaling pathway by p53 class mediator(+) 8 rec.
                                     |__signal transduction in response to DNA damage 42 rec.
                                     |   |__DNA damage checkpoint signaling(+) 38 rec.
                                     |   |__DNA damage response, signal transduction by p53 class mediator 5 rec.
                                     |   |__DNA damage response, signal transduction resulting in transcription
                                     |__stress-activated protein kinase signaling cascade 7 rec.
                                     |   |__stress-activated MAPK cascade(+) 5 rec.
                                     |__TOR signaling 82 rec.
                                         |__TORC1 signaling 60 rec.
                                         |__TORC2 signaling 8 rec.
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Is a signal transduction
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Synonyms
  • "intracellular signal transduction pathway" NARROW
    "intracellular signaling cascade" RELATED
    "intracellular signaling pathway" RELATED
    "signal transmission via intracellular cascade" NARROW
Secondary IDs
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