FB2025_05 , released December 11, 2025

CV Term Report

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General Information
Term	response to topologically incorrect protein	ID (Ontology)	GO:0035966 (Gene Ontology)
Definition	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
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Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
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Spanning Tree (Parents/Children)

  response to stimulus
   |__response to stress
       |__response to topologically incorrect protein  46 rec.
           |__cellular response to topologically incorrect protein 40 rec.
           |   |__cellular response to misfolded protein 6 rec.
           |   |__cellular response to unfolded protein(+) 33 rec.
           |__response to misfolded protein 6 rec.
           |   |__cellular response to misfolded protein 6 rec.
           |   |__detection of misfolded protein
           |__response to unfolded protein 39 rec.
               |__cellular response to unfolded protein(+) 33 rec.
               |__detection of unfolded protein

Spanning Tree View Settings
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Relationships
Is a	response to stress
Part of
Synonyms & Secondary IDs
Synonyms
	"response to misfolded or unfolded protein" RELATED
Secondary IDs

External Crossreferences & Linkouts