FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
Help Close All Open All
General Information
Term proteasome-mediated ubiquitin-dependent protein catabolic process ID (Ontology) GO:0043161 (Gene Ontology)
Definition The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
Also Known As "proteasomal pathway" ; "proteasomal ubiquitin-dependent protein breakdown" ; "proteasomal ubiquitin-dependent protein catabolic process" (for all, see Synonyms field below)
Comment
Links to External Ontologies
  QuickGO data     AmiGO data
Annotations
Records annotated with this term OR any of its CHILD TERMS
    Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS     129
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 proteasome-mediated ubiquitin-dependent protein catabolic process (all annotations which use CV term, excluding "NOT" statements)      13    129
     involved_in | proteasome-mediated ubiquitin-dependent protein catabolic process       --     129
Spanning Tree (Parents/Children)
Only view relationship: 
modification-dependent protein catabolic process
 |__ubiquitin-dependent protein catabolic process__
protein catabolic process                          |
 |__proteasomal protein catabolic process__________|
proteolysis involved in protein catabolic process  |
 |__proteasomal protein catabolic process__________|
                                                   proteasome-mediated ubiquitin-dependent protein catabolic process  270 rec.
                                                    |__anaphase-promoting complex-dependent catabolic process 19 rec.
                                                    |__cytoplasm protein quality control by the ubiquitin-proteasome system
                                                    |__mitochondria-associated ubiquitin-dependent protein catabolic process
                                                    |__negative regulation of transcription by transcription factor catabolism
                                                    |__nuclear protein quality control by the ubiquitin-proteasome system 1 rec.
                                                    |   |__inner nuclear membrane-associated protein degradation pathway
                                                    |__ribosome-associated ubiquitin-dependent protein catabolic process 3 rec.
                                                    |__SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 68 rec.
                                                    |__stress-induced homeostatically regulated protein degradation pathway
                                                    |__ubiquitin-dependent protein catabolic process via the C-end degron rule pathway 1 rec.
                                                    |__ubiquitin-dependent protein catabolic process via the N-end rule pathway 5 rec.
Spanning Tree View Settings
Parents/Children
View Depth
Show hierarchy levels: for parents, for children
hide Relationships
Is a ubiquitin-dependent protein catabolic process
proteasomal protein catabolic process
Part of
hide Synonyms & Secondary IDs
Synonyms
  • "proteasomal pathway" EXACT
    "proteasomal processing" RELATED
    "proteasomal ubiquitin-dependent protein breakdown" EXACT
    "proteasomal ubiquitin-dependent protein catabolic process" EXACT
    "proteasomal ubiquitin-dependent protein catabolism" EXACT
    "proteasomal ubiquitin-dependent protein degradation" EXACT
    "proteasome pathway" RELATED
Secondary IDs
hide External Crossreferences & Linkouts
Reactome:R-HSA-75815 "Ubiquitin-dependent degradation of Cyclin D"