FB2025_05 , released December 11, 2025

CV Term Report

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General Information

Term

positive regulation of MAPK cascade

ID (Ontology)

GO:0043410 (Gene Ontology)

Definition

Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.

Also Known As

"positive regulation of MAP kinase cascade" ; "positive regulation of MAP kinase kinase kinase cascade" ; "positive regulation of MAPKKK cascade" (for all, see Synonyms field below)

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
positive regulation of MAPK cascade (all annotations which use CV term, excluding "NOT" statements)	22
involved_in \| positive regulation of MAPK cascade	22

Spanning Tree (Parents/Children)

positive regulation of signal transduction
 |__positive regulation of intracellular signal transduction__
regulation of intracellular signal transduction               |
 |__regulation of MAPK cascade________________________________|
 |__positive regulation of intracellular signal transduction__|
                                                              positive regulation of MAPK cascade  80 rec.
                                                               |__positive regulation of ERK1 and ERK2 cascade 24 rec.
                                                               |__positive regulation of ERK5 cascade
                                                               |__positive regulation of JNK cascade 37 rec.
                                                               |__positive regulation of MAP kinase activity 1 rec.
                                                               |   |__positive regulation of JUN kinase activity 1 rec.
                                                               |__positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
                                                               |__positive regulation of p38MAPK cascade 1 rec.
                                                               |__positive regulation of pheromone response MAPK cascade
                                                               |__positive regulation of stress-activated MAPK cascade 2 rec.
                                                                   |__positive regulation of cell integrity MAPK cascade

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Relationships
Is a	regulation of MAPK cascade positive regulation of intracellular signal transduction
Part of
Synonyms & Secondary IDs
Synonyms
	"activation of MAPK cascade" NARROW "activation of MAPKKK cascade" NARROW "positive regulation of MAP kinase cascade" EXACT "positive regulation of MAP kinase kinase kinase cascade" EXACT "positive regulation of MAPKKK cascade" EXACT "positive regulation of mitogen activated protein kinase kinase kinase cascade" EXACT "positive regulation of mitogen-activated protein kinase cascade" EXACT "positive regulation of mitogen-activated protein kinase kinase kinase cascade" EXACT "stimulation of MAPK cascade" EXACT "stimulation of MAPKKK cascade" NARROW "up regulation of MAPKKK cascade" EXACT "up-regulation of MAPK cascade" EXACT "up-regulation of MAPKKK cascade" EXACT "upregulation of MAPK cascade" EXACT "upregulation of MAPKKK cascade" EXACT
Secondary IDs

External Crossreferences & Linkouts