FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term regulation of cell differentiation ID (Ontology) GO:0045595 (Gene Ontology)
Definition Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.
Comment
Links to External Ontologies
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       7
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 regulation of cell differentiation (all annotations which use CV term, excluding "NOT" statements)       7
     involved_in | regulation of cell differentiation       7
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of biological process
 |__regulation of developmental process__
 |__regulation of cellular process_______|
                                         regulation of cell differentiation  284 rec.
                                          |__negative regulation of cell differentiation 97 rec.
                                          |   |__maintenance of animal organ identity(+)
                                          |   |__maintenance of imaginal histoblast diploidy 1 rec.
                                          |   |__maintenance of plant organ identity(+)
                                          |   |__negative regulation of antipodal cell differentiation
                                          |   |__negative regulation of cardiac endothelial to mesenchymal transition
                                          |   |__negative regulation of cardiocyte differentiation(+) 5 rec.
                                          |   |__negative regulation of cell development(+) 45 rec.
                                          |   |__negative regulation of cell differentiation involved in embryonic placenta development
                                          |   |__negative regulation of cell differentiation involved in phenotypic switching(+)
                                          |   |__negative regulation of cell differentiation involved in stem cell population maintenance
                                          |   |__negative regulation of cell fate commitment(+) 21 rec.
                                          |   |__negative regulation of chondrocyte differentiation(+)
                                          |   |__negative regulation of embryo sac central cell differentiation
                                          |   |__negative regulation of embryo sac egg cell differentiation
                                          |   |__negative regulation of endodermal cell differentiation(+)
                                          |   |__negative regulation of epithelial cell differentiation(+)
                                          |   |__negative regulation of epithelial to mesenchymal transition(+)
                                          |   |__negative regulation of fat cell differentiation(+)
                                          |   |__negative regulation of hematopoietic progenitor cell differentiation(+) 1 rec.
                                          |   |__negative regulation of hemocyte differentiation(+) 19 rec.
                                          |   |__negative regulation of macrophage derived foam cell differentiation
                                          |   |__negative regulation of mesodermal cell differentiation(+)
                                          |   |__negative regulation of metanephric DCT cell differentiation
                                          |   |__negative regulation of muscle cell differentiation(+) 2 rec.
                                          |   |__negative regulation of myeloid cell differentiation(+)
                                          |   |__negative regulation of myoblast differentiation(+)
                                          |   |__negative regulation of myofibroblast differentiation
                                          |   |__negative regulation of neuron differentiation(+) 15 rec.
                                          |   |__negative regulation of osteoblast differentiation
                                          |   |__negative regulation of pigment cell differentiation(+) 1 rec.
                                          |   |__negative regulation of plant epidermal cell differentiation(+)
                                          |   |__negative regulation of skeletal muscle cell differentiation(+)
                                          |   |__negative regulation of sorocarp spore cell differentiation
                                          |   |__negative regulation of sorocarp stalk cell differentiation
                                          |   |__negative regulation of spermatid nuclear differentiation
                                          |   |__negative regulation of stem cell differentiation(+) 11 rec.
                                          |   |__negative regulation of synergid differentiation
                                          |   |__negative regulation of tendon cell differentiation
                                          |   |__negative regulation of transdifferentiation
                                          |   |__negative regulation of vasculogenesis
                                          |__positive regulation of cell differentiation 130 rec.
                                          |   |__positive regulation of antipodal cell differentiation
                                          |   |__positive regulation of cardiac endothelial to mesenchymal transition
                                          |   |__positive regulation of cardiocyte differentiation(+) 1 rec.
                                          |   |__positive regulation of cell development(+) 92 rec.
                                          |   |__positive regulation of cell differentiation involved in phenotypic switching(+)
                                          |   |__positive regulation of cell fate commitment(+)
                                          |   |__positive regulation of chondrocyte differentiation(+)
                                          |   |__positive regulation of embryo sac central cell differentiation
                                          |   |__positive regulation of embryo sac egg cell differentiation
                                          |   |__positive regulation of endodermal cell differentiation
                                          |   |__positive regulation of epithelial cell differentiation(+) 1 rec.
                                          |   |__positive regulation of epithelial to mesenchymal transition(+)
                                          |   |__positive regulation of fat cell differentiation(+)
                                          |   |__positive regulation of hematopoietic progenitor cell differentiation(+)
                                          |   |__positive regulation of hemocyte differentiation(+) 7 rec.
                                          |   |__positive regulation of macrophage derived foam cell differentiation
                                          |   |__positive regulation of mesodermal cell differentiation(+)
                                          |   |__positive regulation of mesodermal cell fate determination(+)
                                          |   |__positive regulation of metanephric DCT cell differentiation
                                          |   |__positive regulation of muscle cell differentiation(+) 4 rec.
                                          |   |__positive regulation of myeloid cell differentiation(+)
                                          |   |__positive regulation of myoblast differentiation(+) 1 rec.
                                          |   |__positive regulation of myofibroblast differentiation
                                          |   |__positive regulation of neuron differentiation(+) 22 rec.
                                          |   |__positive regulation of osteoblast differentiation
                                          |   |__positive regulation of pigment cell differentiation(+)
                                          |   |__positive regulation of plant epidermal cell differentiation(+)
                                          |   |__positive regulation of sclerenchyma cell differentiation
                                          |   |__positive regulation of skeletal muscle cell differentiation(+)
                                          |   |__positive regulation of sorocarp spore cell differentiation
                                          |   |__positive regulation of sorocarp stalk cell differentiation
                                          |   |__positive regulation of spermatid nuclear differentiation
                                          |   |__positive regulation of stem cell differentiation(+) 5 rec.
                                          |   |__positive regulation of synergid differentiation
                                          |   |__positive regulation of tendon cell differentiation
                                          |   |__positive regulation of transdifferentiation
                                          |   |__positive regulation of vasculogenesis
                                          |__regulation of antipodal cell differentiation
                                          |   |__negative regulation of antipodal cell differentiation
                                          |   |__positive regulation of antipodal cell differentiation
                                          |__regulation of cardiac endothelial to mesenchymal transition
                                          |   |__negative regulation of cardiac endothelial to mesenchymal transition
                                          |   |__positive regulation of cardiac endothelial to mesenchymal transition
                                          |__regulation of cardiocyte differentiation 7 rec.
                                          |   |__negative regulation of cardiocyte differentiation(+) 5 rec.
                                          |   |__positive regulation of cardiocyte differentiation(+) 1 rec.
                                          |   |__regulation of cardiac cell fate specification(+) 5 rec.
                                          |   |__regulation of cardiac muscle cell differentiation(+) 1 rec.
                                          |   |__regulation of cardiac vascular smooth muscle cell differentiation(+)
                                          |   |__regulation of cardioblast differentiation(+) 6 rec.
                                          |   |__regulation of endocardial cushion cell differentiation(+)
                                          |__regulation of cell development 180 rec.
                                          |   |__modulation of spore encystment on host(+)
                                          |   |__negative regulation of cell development(+) 45 rec.
                                          |   |__negative regulation of respiratory burst involved in inflammatory response
                                          |   |__positive regulation of cell development(+) 92 rec.
                                          |   |__regulation of ascospore formation(+)
                                          |   |__regulation of cardiac muscle fiber development(+)
                                          |   |__regulation of cardiac myofibril assembly(+) 2 rec.
                                          |   |__regulation of cell maturation(+) 20 rec.
                                          |   |__regulation of cerebellar neuron development(+)
                                          |   |__regulation of chondrocyte development(+)
                                          |   |__regulation of conidium formation(+)
                                          |   |__regulation of endothelial cell development(+)
                                          |   |__regulation of establishment of blood-brain barrier(+) 4 rec.
                                          |   |__regulation of establishment of Sertoli cell barrier(+)
                                          |   |__regulation of eye photoreceptor cell development(+) 13 rec.
                                          |   |__regulation of hemopoiesis(+) 12 rec.
                                          |   |__regulation of Hulle cell development(+)
                                          |   |__regulation of intestinal epithelial cell development(+)
                                          |   |__regulation of metanephric podocyte development(+)
                                          |   |__regulation of metula development(+)
                                          |   |__regulation of neurogenesis(+) 134 rec.
                                          |   |__regulation of oogenesis(+) 3 rec.
                                          |   |__regulation of phialide development(+)
                                          |   |__regulation of skeletal muscle fiber development(+)
                                          |   |__regulation of type B pancreatic cell development(+)
                                          |__regulation of cell differentiation involved in embryonic placenta development
                                          |   |__negative regulation of cell differentiation involved in embryonic placenta development
                                          |__regulation of cell differentiation involved in phenotypic switching
                                          |   |__negative regulation of cell differentiation involved in phenotypic switching(+)
                                          |   |__positive regulation of cell differentiation involved in phenotypic switching(+)
                                          |   |__regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching(+)
                                          |__regulation of cell differentiation involved in tissue homeostasis 2 rec.
                                          |__regulation of chondrocyte differentiation
                                          |   |__negative regulation of chondrocyte differentiation(+)
                                          |   |__positive regulation of chondrocyte differentiation(+)
                                          |   |__regulation of chondrocyte development(+)
                                          |   |__regulation of chondrocyte differentiation involved in endochondral bone morphogenesis(+)
                                          |__regulation of embryo sac central cell differentiation
                                          |   |__negative regulation of embryo sac central cell differentiation
                                          |   |__positive regulation of embryo sac central cell differentiation
                                          |__regulation of embryo sac egg cell differentiation
                                          |   |__negative regulation of embryo sac egg cell differentiation
                                          |   |__positive regulation of embryo sac egg cell differentiation
                                          |__regulation of endodermal cell differentiation
                                          |   |__negative regulation of endodermal cell differentiation(+)
                                          |   |__positive regulation of endodermal cell differentiation
                                          |   |__regulation of endodermal cell fate specification(+)
                                          |__regulation of epithelial cell differentiation 4 rec.
                                          |   |__negative regulation of epithelial cell differentiation(+)
                                          |   |__positive regulation of epithelial cell differentiation(+) 1 rec.
                                          |   |__regulation of cumulus cell differentiation(+)
                                          |   |__regulation of endothelial cell differentiation(+)
                                          |   |__regulation of epidermal cell differentiation(+) 1 rec.
                                          |   |__regulation of epithelial cell differentiation involved in kidney development(+)
                                          |   |__regulation of hepatocyte differentiation(+)
                                          |   |__regulation of intestinal epithelial cell development(+)
                                          |   |__regulation of lens fiber cell differentiation(+)
                                          |   |__regulation of lung ciliated cell differentiation(+)
                                          |   |__regulation of lung goblet cell differentiation(+)
                                          |   |__regulation of odontoblast differentiation(+)
                                          |   |__regulation of pancreatic A cell differentiation(+)
                                          |   |__regulation of polarized epithelial cell differentiation(+) 2 rec.
                                          |   |__regulation of stomach neuroendocrine cell differentiation(+)
                                          |__regulation of epithelial to mesenchymal transition
                                          |   |__negative regulation of epithelial to mesenchymal transition(+)
                                          |   |__positive regulation of epithelial to mesenchymal transition(+)
                                          |   |__regulation of cardiac epithelial to mesenchymal transition(+)
                                          |   |__regulation of neural crest formation(+)
                                          |__regulation of fat cell differentiation
                                          |   |__negative regulation of fat cell differentiation(+)
                                          |   |__positive regulation of fat cell differentiation(+)
                                          |   |__regulation of brown fat cell differentiation(+)
                                          |__regulation of glial cell differentiation 2 rec.
                                          |   |__negative regulation of glial cell differentiation(+)
                                          |   |__positive regulation of glial cell differentiation(+) 2 rec.
                                          |   |__regulation of astrocyte differentiation(+)
                                          |   |__regulation of microglia differentiation(+)
                                          |   |__regulation of oligodendrocyte differentiation(+)
                                          |   |__regulation of Schwann cell differentiation(+)
                                          |__regulation of hematopoietic progenitor cell differentiation 1 rec.
                                          |   |__negative regulation of hematopoietic progenitor cell differentiation(+) 1 rec.
                                          |   |__positive regulation of hematopoietic progenitor cell differentiation(+)
                                          |   |__regulation of hematopoietic stem cell differentiation(+) 1 rec.
                                          |   |__regulation of lymphoid progenitor cell differentiation(+)
                                          |   |__regulation of myeloid progenitor cell differentiation(+)
                                          |__regulation of hemocyte differentiation 25 rec.
                                          |   |__negative regulation of hemocyte differentiation(+) 19 rec.
                                          |   |__positive regulation of hemocyte differentiation(+) 7 rec.
                                          |   |__regulation of crystal cell differentiation(+) 13 rec.
                                          |   |__regulation of lamellocyte differentiation(+) 11 rec.
                                          |   |__regulation of plasmatocyte differentiation(+) 4 rec.
                                          |__regulation of macrophage derived foam cell differentiation
                                          |   |__negative regulation of macrophage derived foam cell differentiation
                                          |   |__positive regulation of macrophage derived foam cell differentiation
                                          |__regulation of mesodermal cell differentiation
                                          |   |__negative regulation of mesodermal cell differentiation(+)
                                          |   |__positive regulation of mesodermal cell differentiation(+)
                                          |   |__regulation of mesodermal cell fate determination(+)
                                          |   |__regulation of mesodermal cell fate specification(+)
                                          |__regulation of metanephric DCT cell differentiation
                                          |   |__negative regulation of metanephric DCT cell differentiation
                                          |   |__positive regulation of metanephric DCT cell differentiation
                                          |__regulation of muscle cell differentiation 5 rec.
                                          |   |__negative regulation of muscle cell differentiation(+) 2 rec.
                                          |   |__positive regulation of muscle cell differentiation(+) 4 rec.
                                          |   |__regulation of smooth muscle cell differentiation(+)
                                          |   |__regulation of striated muscle cell differentiation(+) 3 rec.
                                          |__regulation of myoblast differentiation 2 rec.
                                          |   |__negative regulation of myoblast differentiation(+)
                                          |   |__positive regulation of myoblast differentiation(+) 1 rec.
                                          |   |__regulation of cardiac muscle cell myoblast differentiation(+)
                                          |__regulation of myofibroblast differentiation
                                          |   |__negative regulation of myofibroblast differentiation
                                          |   |__positive regulation of myofibroblast differentiation
                                          |__regulation of neuron differentiation 90 rec.
                                          |   |__negative regulation of neuron differentiation(+) 15 rec.
                                          |   |__positive regulation of neuron differentiation(+) 22 rec.
                                          |   |__regulation of amacrine cell differentiation(+)
                                          |   |__regulation of cerebellar neuron development(+)
                                          |   |__regulation of dopaminergic neuron differentiation(+) 1 rec.
                                          |   |__regulation of forebrain neuron differentiation(+)
                                          |   |__regulation of glutamatergic neuron differentiation(+)
                                          |   |__regulation of mechanoreceptor differentiation(+)
                                          |   |__regulation of neuron maturation(+) 20 rec.
                                          |   |__regulation of photoreceptor cell differentiation(+) 47 rec.
                                          |   |__regulation of spinal cord association neuron differentiation(+)
                                          |   |__regulation of stomach neuroendocrine cell differentiation(+)
                                          |   |__regulation of timing of neuron differentiation(+)
                                          |__regulation of osteoblast differentiation
                                          |   |__negative regulation of osteoblast differentiation
                                          |   |__positive regulation of osteoblast differentiation
                                          |__regulation of pigment cell differentiation 1 rec.
                                          |   |__negative regulation of pigment cell differentiation(+) 1 rec.
                                          |   |__positive regulation of pigment cell differentiation(+)
                                          |   |__regulation of cyanophore differentiation(+)
                                          |   |__regulation of erythrophore differentiation(+)
                                          |   |__regulation of iridophore differentiation(+)
                                          |   |__regulation of leucophore differentiation(+)
                                          |   |__regulation of melanocyte differentiation(+)
                                          |   |__regulation of xanthophore differentiation(+)
                                          |__regulation of plant epidermal cell differentiation
                                          |   |__negative regulation of plant epidermal cell differentiation(+)
                                          |   |__positive regulation of plant epidermal cell differentiation(+)
                                          |   |__regulation of atrichoblast fate specification(+)
                                          |   |__regulation of trichoblast fate specification(+)
                                          |__regulation of sclerenchyma cell differentiation
                                          |   |__positive regulation of sclerenchyma cell differentiation
                                          |__regulation of skeletal muscle cell differentiation
                                          |   |__negative regulation of skeletal muscle cell differentiation(+)
                                          |   |__positive regulation of skeletal muscle cell differentiation(+)
                                          |   |__regulation of skeletal muscle fiber differentiation(+)
                                          |__regulation of sorocarp spore cell differentiation
                                          |   |__cheating during chimeric sorocarp development
                                          |   |__negative regulation of sorocarp spore cell differentiation
                                          |   |__positive regulation of sorocarp spore cell differentiation
                                          |__regulation of sorocarp stalk cell differentiation
                                          |   |__negative regulation of sorocarp stalk cell differentiation
                                          |   |__positive regulation of sorocarp stalk cell differentiation
                                          |__regulation of stem cell differentiation 23 rec.
                                          |   |__negative regulation of stem cell differentiation(+) 11 rec.
                                          |   |__positive regulation of stem cell differentiation(+) 5 rec.
                                          |   |__regulation of cardioblast differentiation(+) 6 rec.
                                          |   |__regulation of hematopoietic stem cell differentiation(+) 1 rec.
                                          |   |__regulation of mesenchymal stem cell differentiation(+)
                                          |   |__regulation of neural crest cell differentiation(+)
                                          |__regulation of synergid differentiation
                                          |   |__negative regulation of synergid differentiation
                                          |   |__positive regulation of synergid differentiation
                                          |__regulation of tendon cell differentiation
                                          |   |__negative regulation of tendon cell differentiation
                                          |   |__positive regulation of tendon cell differentiation
                                          |__regulation of timing of cell differentiation
                                          |   |__inhibition of neuroepithelial cell differentiation(+)
                                          |   |__regulation of timing of neuron differentiation(+)
                                          |__regulation of transdifferentiation
                                          |   |__negative regulation of transdifferentiation
                                          |   |__positive regulation of transdifferentiation
                                          |__regulation of trichome morphogenesis
                                          |__regulation of trichome patterning
                                          |   |__negative regulation of trichome patterning
                                          |__regulation of vasculogenesis
                                              |__negative regulation of vasculogenesis
                                              |__positive regulation of vasculogenesis
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Is a regulation of developmental process
regulation of cellular process
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