FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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Term negative regulation of response to stimulus ID (Ontology) GO:0048585 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a stimulus. Response to stimulus is a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus.
Also Known As "down regulation of response to stimulus" ; "down-regulation of response to stimulus" ; "downregulation of response to stimulus"
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regulation of biological process
 |__negative regulation of biological process__
 |__regulation of response to stimulus_________|
                                               negative regulation of response to stimulus  510 rec.
                                                |__negative regulation of cellular response to alkaline pH
                                                |__negative regulation of cellular response to caffeine
                                                |__negative regulation of cellular response to growth factor stimulus 58 rec.
                                                |   |__negative regulation of BMP signaling pathway(+) 43 rec.
                                                |   |__negative regulation of cell chemotaxis to fibroblast growth factor(+)
                                                |   |__negative regulation of cellular response to hepatocyte growth factor stimulus
                                                |   |__negative regulation of cellular response to transforming growth factor beta stimulus
                                                |   |__negative regulation of cellular response to vascular endothelial growth factor stimulus(+)
                                                |   |__negative regulation of fibroblast growth factor receptor signaling pathway(+) 9 rec.
                                                |   |__negative regulation of neurotrophin TRK receptor signaling pathway
                                                |   |__negative regulation of vascular endothelial growth factor receptor signaling pathway 8 rec.
                                                |__negative regulation of cellular response to heat
                                                |__negative regulation of cellular response to hypoxia 1 rec.
                                                |   |__negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
                                                |   |__negative regulation of hypoxia-inducible factor-1alpha signaling pathway
                                                |__negative regulation of cellular response to insulin stimulus 32 rec.
                                                |   |__negative regulation of insulin receptor signaling pathway(+) 32 rec.
                                                |__negative regulation of cellular response to manganese ion
                                                |__negative regulation of cellular response to oxidopamine
                                                |__negative regulation of cellular response to testosterone stimulus
                                                |__negative regulation of cellular response to very-low-density lipoprotein particle stimulus
                                                |__negative regulation of cellular response to X-ray
                                                |__negative regulation of defense response 90 rec.
                                                |   |__negative regulation of antimicrobial humoral response(+) 24 rec.
                                                |   |__negative regulation of behavioral fear response
                                                |   |__negative regulation of cellular defense response
                                                |   |__negative regulation of defense response to bacterium(+) 49 rec.
                                                |   |__negative regulation of defense response to insect
                                                |   |__negative regulation of defense response to oomycetes
                                                |   |__negative regulation of defense response to virus(+)
                                                |   |__negative regulation of inflammatory response(+) 1 rec.
                                                |   |__negative regulation of innate immune response(+) 39 rec.
                                                |   |__negative regulation of neutrophil mediated killing of symbiont cell(+)
                                                |   |__negative regulation of systemic acquired resistance
                                                |   |__negative regulation of xenophagy
                                                |__negative regulation of detection of glucose
                                                |__negative regulation of DNA repair 2 rec.
                                                |   |__negative regulation of base-excision repair
                                                |   |__negative regulation of double-strand break repair(+) 2 rec.
                                                |   |__negative regulation of mismatch repair
                                                |   |__negative regulation of single strand break repair(+)
                                                |__negative regulation of error-prone translesion synthesis
                                                |__negative regulation of establishment of competence for transformation
                                                |__negative regulation of fear response
                                                |   |__negative regulation of behavioral fear response
                                                |__negative regulation of filamentous growth of a population of unicellular organisms in response to chemical stimulus
                                                |__negative regulation of filamentous growth of a population of unicellular organisms in response to heat
                                                |__negative regulation of filamentous growth of a population of unicellular organisms in response to pH
                                                |   |__negative regulation of filamentous growth of a population of unicellular organisms in response to neutral pH
                                                |__negative regulation of immune response 67 rec.
                                                |   |__negative regulation of adaptive immune response(+)
                                                |   |__negative regulation of basophil degranulation
                                                |   |__negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                                |   |__negative regulation of eosinophil degranulation
                                                |   |__negative regulation of gamma-delta T cell activation involved in immune response
                                                |   |__negative regulation of humoral immune response(+) 27 rec.
                                                |   |__negative regulation of immune response to tumor cell(+)
                                                |   |__negative regulation of inflammatory response to antigenic stimulus(+)
                                                |   |__negative regulation of innate immune response(+) 39 rec.
                                                |   |__negative regulation of mast cell activation involved in immune response
                                                |   |__negative regulation of memory T cell differentiation
                                                |   |__negative regulation of natural killer cell differentiation involved in immune response
                                                |   |__negative regulation of natural killer cell proliferation involved in immune response
                                                |   |__negative regulation of neutrophil degranulation
                                                |   |__negative regulation of plasma cell differentiation
                                                |   |__negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                                |   |__negative regulation of T-helper cell differentiation(+)
                                                |   |__negative regulation of type 2 immune response(+)
                                                |__negative regulation of insulin secretion involved in cellular response to glucose stimulus
                                                |__negative regulation of long-day photoperiodism, flowering
                                                |__negative regulation of muscle adaptation
                                                |   |__negative regulation of cardiac muscle adaptation(+)
                                                |   |__negative regulation of muscle atrophy
                                                |   |__negative regulation of muscle hyperplasia
                                                |   |__negative regulation of skeletal muscle hypertrophy
                                                |   |__negative regulation of smooth muscle hypertrophy
                                                |__negative regulation of neuron projection regeneration 3 rec.
                                                |   |__negative regulation of axon regeneration(+) 3 rec.
                                                |__negative regulation of photomorphogenesis
                                                |__negative regulation of response to acetate
                                                |__negative regulation of response to alcohol 3 rec.
                                                |   |__negative regulation of cellular response to alcohol(+) 3 rec.
                                                |   |__negative regulation of response to butan-1-ol
                                                |   |__negative regulation of response to ethanol
                                                |   |__negative regulation of response to propan-1-ol
                                                |__negative regulation of response to amylopectin
                                                |__negative regulation of response to benzene
                                                |__negative regulation of response to biotic stimulus 89 rec.
                                                |   |__negative regulation of antimicrobial humoral response(+) 24 rec.
                                                |   |__negative regulation of defense response to bacterium(+) 49 rec.
                                                |   |__negative regulation of defense response to insect
                                                |   |__negative regulation of defense response to oomycetes
                                                |   |__negative regulation of defense response to virus(+)
                                                |   |__negative regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus
                                                |   |__negative regulation of innate immune response(+) 39 rec.
                                                |   |__negative regulation of lipopolysaccharide-mediated signaling pathway(+)
                                                |   |__negative regulation of neutrophil mediated killing of symbiont cell(+)
                                                |   |__negative regulation of response to tumor cell(+)
                                                |   |__negative regulation of systemic acquired resistance
                                                |   |__negative regulation of xenophagy
                                                |__negative regulation of response to calcium ion
                                                |__negative regulation of response to cycloalkane
                                                |__negative regulation of response to cytokine stimulus 6 rec.
                                                |   |__negative regulation of cytokine-mediated signaling pathway(+) 6 rec.
                                                |   |__negative regulation of response to macrophage colony-stimulating factor(+)
                                                |   |__negative regulation of response to type II interferon(+)
                                                |__negative regulation of response to drug
                                                |   |__negative regulation of cellular response to drug
                                                |   |__negative regulation of xenobiotic detoxification by transmembrane export across the plasma membrane
                                                |__negative regulation of response to endoplasmic reticulum stress 5 rec.
                                                |   |__negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(+) 1 rec.
                                                |   |__negative regulation of endoplasmic reticulum unfolded protein response(+) 2 rec.
                                                |   |__negative regulation of ERAD pathway 2 rec.
                                                |__negative regulation of response to external stimulus 111 rec.
                                                |   |__negative regulation of antimicrobial humoral response(+) 24 rec.
                                                |   |__negative regulation of axon regeneration(+) 3 rec.
                                                |   |__negative regulation of chemokinesis
                                                |   |__negative regulation of chemotaxis(+) 2 rec.
                                                |   |__negative regulation of defense response to bacterium(+) 49 rec.
                                                |   |__negative regulation of defense response to insect
                                                |   |__negative regulation of defense response to oomycetes
                                                |   |__negative regulation of defense response to virus(+)
                                                |   |__negative regulation of detection of mechanical stimulus involved in sensory perception of touch
                                                |   |__negative regulation of inflammatory response(+) 1 rec.
                                                |   |__negative regulation of innate immune response(+) 39 rec.
                                                |   |__negative regulation of lipopolysaccharide-mediated signaling pathway(+)
                                                |   |__negative regulation of mechanosensory behavior
                                                |   |__negative regulation of neutrophil mediated killing of symbiont cell(+)
                                                |   |__negative regulation of opsin-mediated signaling pathway(+) 15 rec.
                                                |   |__negative regulation of systemic acquired resistance
                                                |   |__negative regulation of wound healing(+) 2 rec.
                                                |   |__negative regulation of xenophagy
                                                |   |__prepulse inhibition
                                                |__negative regulation of response to formic acid
                                                |__negative regulation of response to furfural
                                                |__negative regulation of response to gamma radiation 4 rec.
                                                |   |__negative regulation of cellular response to gamma radiation
                                                |__negative regulation of response to nutrient levels
                                                |   |__negative regulation of aggregation involved in sorocarp development
                                                |   |__negative regulation of cellular response to amino acid starvation
                                                |   |__negative regulation of cellular response to iron ion starvation
                                                |   |__negative regulation of cellular response to nitrogen starvation
                                                |   |__negative regulation of cellular response to phosphate starvation
                                                |   |__negative regulation of nitrogen utilization(+)
                                                |   |__negative regulation of response to food(+)
                                                |   |__negative regulation of sorocarp stalk cell differentiation
                                                |   |__negative regulation of sulfur utilization
                                                |__negative regulation of response to oxidative stress 2 rec.
                                                |   |__negative regulation of cellular response to oxidative stress(+) 2 rec.
                                                |   |__negative regulation of response to reactive oxygen species(+) 1 rec.
                                                |__negative regulation of response to pullulan
                                                |__negative regulation of response to salt stress
                                                |   |__negative regulation of cellular hyperosmotic salinity response
                                                |__negative regulation of response to toluene
                                                |__negative regulation of response to water deprivation
                                                |__negative regulation of response to wounding 5 rec.
                                                |   |__negative regulation of axon regeneration(+) 3 rec.
                                                |   |__negative regulation of inflammatory response to wounding
                                                |   |__negative regulation of wound healing(+) 2 rec.
                                                |__negative regulation of shade avoidance
                                                |__negative regulation of short-day photoperiodism, flowering
                                                |__negative regulation of signal transduction 459 rec.
                                                |   |__extracellular negative regulation of signal transduction(+)
                                                |   |__negative adaptation of signaling pathway(+) 4 rec.
                                                |   |__negative regulation of abscisic acid-activated signaling pathway
                                                |   |__negative regulation of antigen receptor-mediated signaling pathway(+)
                                                |   |__negative regulation of apolipoprotein A-I-mediated signaling pathway
                                                |   |__negative regulation of apoptotic signaling pathway(+) 22 rec.
                                                |   |__negative regulation of auxin mediated signaling pathway
                                                |   |__negative regulation of brain-derived neurotrophic factor receptor signaling pathway
                                                |   |__negative regulation of brassinosteroid mediated signaling pathway
                                                |   |__negative regulation of CD40 signaling pathway
                                                |   |__negative regulation of corticotropin-releasing hormone receptor activity
                                                |   |__negative regulation of cytokine activity(+)
                                                |   |__negative regulation of cytokine-mediated signaling pathway(+) 6 rec.
                                                |   |__negative regulation of cytokinin-activated signaling pathway
                                                |   |__negative regulation of ephrin receptor signaling pathway
                                                |   |__negative regulation of ERBB signaling pathway(+) 40 rec.
                                                |   |__negative regulation of Fas signaling pathway
                                                |   |__negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
                                                |   |__negative regulation of fibroblast growth factor receptor signaling pathway(+) 9 rec.
                                                |   |__negative regulation of G protein-coupled receptor signaling pathway(+) 20 rec.
                                                |   |__negative regulation of GDF15-GFRAL signaling pathway
                                                |   |__negative regulation of gibberellic acid mediated signaling pathway
                                                |   |__negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
                                                |   |__negative regulation of glucose mediated signaling pathway(+)
                                                |   |__negative regulation of glutamate receptor signaling pathway
                                                |   |__negative regulation of growth hormone receptor signaling pathway
                                                |   |__negative regulation of hepatocyte growth factor receptor signaling pathway
                                                |   |__negative regulation of insulin receptor signaling pathway(+) 32 rec.
                                                |   |__negative regulation of insulin-like growth factor receptor signaling pathway 1 rec.
                                                |   |__negative regulation of integrin-mediated signaling pathway
                                                |   |__negative regulation of intracellular signal transduction(+) 153 rec.
                                                |   |__negative regulation of lipopolysaccharide-mediated signaling pathway(+)
                                                |   |__negative regulation of netrin-activated signaling pathway
                                                |   |__negative regulation of neuronal signal transduction 1 rec.
                                                |   |__negative regulation of neurotrophin TRK receptor signaling pathway
                                                |   |__negative regulation of Notch signaling pathway(+) 45 rec.
                                                |   |__negative regulation of peptidoglycan recognition protein signaling pathway 47 rec.
                                                |   |__negative regulation of platelet-derived growth factor receptor signaling pathway(+)
                                                |   |__negative regulation of receptor guanylyl cyclase signaling pathway
                                                |   |__negative regulation of receptor signaling pathway via STAT(+) 21 rec.
                                                |   |__negative regulation of red or far-red light signaling pathway
                                                |   |__negative regulation of Roundabout signaling pathway(+)
                                                |   |__negative regulation of semaphorin-plexin signaling pathway 1 rec.
                                                |   |__negative regulation of sevenless signaling pathway 6 rec.
                                                |   |__negative regulation of signal transduction by receptor internalization(+)
                                                |   |__negative regulation of signal transduction in absence of ligand(+) 1 rec.
                                                |   |__negative regulation of signal transduction involved in conjugation with cellular fusion(+)
                                                |   |__negative regulation of smoothened signaling pathway(+) 60 rec.
                                                |   |__negative regulation of sphingolipid mediated signaling pathway
                                                |   |__negative regulation of Toll signaling pathway 20 rec.
                                                |   |__negative regulation of toll-like receptor 1 signaling pathway
                                                |   |__negative regulation of toll-like receptor 2 signaling pathway
                                                |   |__negative regulation of toll-like receptor 4 signaling pathway
                                                |   |__negative regulation of toll-like receptor 5 signaling pathway
                                                |   |__negative regulation of toll-like receptor 6 signaling pathway
                                                |   |__negative regulation of toll-like receptor 10 signaling pathway
                                                |   |__negative regulation of toll-like receptor 15 signaling pathway
                                                |   |__negative regulation of toll-like receptor signaling pathway(+)
                                                |   |__negative regulation of torso signaling pathway 8 rec.
                                                |   |__negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway(+) 46 rec.
                                                |   |__negative regulation of vascular endothelial growth factor receptor signaling pathway 8 rec.
                                                |   |__negative regulation of vascular endothelial growth factor signaling pathway
                                                |   |__negative regulation of Wnt signaling pathway(+) 53 rec.
                                                |   |__termination of signal transduction(+)
                                                |__negative regulation of stress response to copper ion
                                                |__negative regulation of telomere maintenance in response to DNA damage
                                                |   |__negative regulation of protection from non-homologous end joining at telomere
                                                |__negative regulation of thermomorphogenesis
                                                |__negative regulation of vernalization response
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Is a negative regulation of biological process
regulation of response to stimulus
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Synonyms
  • "down regulation of response to stimulus" EXACT
    "down-regulation of response to stimulus" EXACT
    "downregulation of response to stimulus" EXACT
    "inhibition of response to stimulus" NARROW
Secondary IDs
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