FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
CV Term Report
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General Information
Term negative regulation of immune response ID (Ontology) GO:0050777 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
Also Known As "down regulation of immune response" ; "down-regulation of immune response" ; "downregulation of immune response"
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Annotations
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS       5
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 Full annotation statements 
Relevant FlyBase reports
 Genes
 negative regulation of immune response (all annotations which use CV term, excluding "NOT" statements)       5
     acts_upstream_of | negative regulation of immune response       1
     involved_in | negative regulation of immune response       4
Spanning Tree (Parents/Children)
Only view relationship: 
regulation of immune system process
 |__negative regulation of immune system process__
 |__regulation of immune response_________________|
negative regulation of biological process         |
 |__negative regulation of immune system process__|
 |__negative regulation of response to stimulus___|
regulation of response to stimulus                |
 |__negative regulation of response to stimulus___|
 |__regulation of immune response_________________|
                                                  negative regulation of immune response  67 rec.
                                                   |__negative regulation of adaptive immune response
                                                   |   |__negative regulation of adaptive immune effector response
                                                   |   |__negative regulation of adaptive immune memory response
                                                   |   |__negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains(+)
                                                   |__negative regulation of basophil degranulation
                                                   |__negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
                                                   |__negative regulation of eosinophil degranulation
                                                   |__negative regulation of gamma-delta T cell activation involved in immune response
                                                   |__negative regulation of humoral immune response 27 rec.
                                                   |   |__negative regulation of antimicrobial humoral response(+) 24 rec.
                                                   |   |__negative regulation of complement activation(+)
                                                   |   |__negative regulation of humoral immune response mediated by circulating immunoglobulin(+)
                                                   |__negative regulation of immune response to tumor cell
                                                   |   |__negative regulation of natural killer cell mediated immune response to tumor cell(+)
                                                   |   |__negative regulation of T cell mediated immune response to tumor cell(+)
                                                   |   |__negative regulation of tolerance induction to tumor cell(+)
                                                   |__negative regulation of inflammatory response to antigenic stimulus
                                                   |   |__negative regulation of acute inflammatory response to antigenic stimulus(+)
                                                   |   |__negative regulation of chronic inflammatory response to antigenic stimulus
                                                   |__negative regulation of innate immune response 39 rec.
                                                   |   |__negative regulation of age-related resistance
                                                   |   |__negative regulation of antifungal innate immune response 2 rec.
                                                   |   |__negative regulation of complement activation, alternative pathway
                                                   |   |__negative regulation of complement activation, lectin pathway
                                                   |   |__negative regulation of innate immunity memory response
                                                   |   |__negative regulation of melanization defense response(+) 5 rec.
                                                   |   |__negative regulation of natural killer cell mediated immunity(+)
                                                   |   |__negative regulation of plant-type hypersensitive response
                                                   |   |__negative regulation of respiratory burst involved in inflammatory response
                                                   |   |__negative regulation of response to type II interferon(+)
                                                   |   |__negative regulation of type I interferon-mediated signaling pathway
                                                   |__negative regulation of mast cell activation involved in immune response
                                                   |__negative regulation of memory T cell differentiation
                                                   |__negative regulation of natural killer cell differentiation involved in immune response
                                                   |__negative regulation of natural killer cell proliferation involved in immune response
                                                   |__negative regulation of neutrophil degranulation
                                                   |__negative regulation of plasma cell differentiation
                                                   |__negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
                                                   |__negative regulation of T-helper cell differentiation
                                                   |   |__negative regulation of T-helper 1 cell differentiation
                                                   |   |__negative regulation of T-helper 2 cell differentiation
                                                   |   |__negative regulation of T-helper 17 cell differentiation(+)
                                                   |__negative regulation of type 2 immune response
                                                       |__negative regulation of T-helper 2 cell cytokine production
                                                       |__negative regulation of T-helper 2 cell differentiation
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Is a negative regulation of immune system process
negative regulation of response to stimulus
regulation of immune response
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Synonyms
  • "down regulation of immune response" EXACT
    "down-regulation of immune response" EXACT
    "downregulation of immune response" EXACT
    "inhibition of immune response" NARROW
Secondary IDs
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