FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term negative regulation of multicellular organismal process ID (Ontology) GO:0051241 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs.
Also Known As "down regulation of multicellular organismal process" ; "down-regulation of multicellular organismal process" ; "downregulation of multicellular organismal process"
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regulation of biological process
 |__negative regulation of biological process_______
 |__regulation of multicellular organismal process__|
                                                    negative regulation of multicellular organismal process  179 rec.
                                                     |__negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
                                                     |__negative regulation of adiponectin secretion
                                                     |__negative regulation of adipose tissue development
                                                     |__negative regulation of amyloid-beta clearance
                                                     |__negative regulation of animal organ morphogenesis
                                                     |   |__negative regulation of nematode pharynx morphogenesis
                                                     |   |__negative regulation of odontogenesis(+)
                                                     |   |__negative regulation of otic vesicle morphogenesis
                                                     |__negative regulation of apical ectodermal ridge formation
                                                     |__negative regulation of behavior 19 rec.
                                                     |   |__negative regulation of behavioral fear response
                                                     |   |__negative regulation of circadian sleep/wake cycle, sleep(+) 5 rec.
                                                     |   |__negative regulation of circadian sleep/wake cycle, wakefulness
                                                     |   |__negative regulation of egg-laying behavior
                                                     |   |__negative regulation of feeding behavior(+) 11 rec.
                                                     |   |__negative regulation of foraging behavior
                                                     |   |__negative regulation of host-seeking behavior
                                                     |   |__negative regulation of locomotion involved in locomotory behavior 1 rec.
                                                     |   |__negative regulation of locomotor rhythm 2 rec.
                                                     |   |__negative regulation of male mating behavior(+) 1 rec.
                                                     |   |__negative regulation of mechanosensory behavior
                                                     |__negative regulation of blood circulation 3 rec.
                                                     |   |__negative regulation of cerebral blood circulation
                                                     |   |__negative regulation of gastric mucosal blood circulation
                                                     |   |__negative regulation of heart contraction(+) 3 rec.
                                                     |__negative regulation of bone development
                                                     |__negative regulation of branching involved in lung morphogenesis
                                                     |   |__negative regulation of bud outgrowth involved in lung branching
                                                     |__negative regulation of branching involved in ureteric bud morphogenesis
                                                     |__negative regulation of branching morphogenesis of a nerve
                                                     |__negative regulation of cardiac endothelial to mesenchymal transition
                                                     |__negative regulation of cardiac ventricle development
                                                     |   |__negative regulation of cardiac ventricle formation
                                                     |__negative regulation of cardiocyte differentiation 5 rec.
                                                     |   |__negative regulation of cardiac cell fate specification(+) 4 rec.
                                                     |   |__negative regulation of cardiac muscle cell differentiation(+) 1 rec.
                                                     |   |__negative regulation of cardiac vascular smooth muscle cell differentiation
                                                     |   |__negative regulation of cardioblast differentiation(+) 4 rec.
                                                     |   |__negative regulation of endocardial cushion cell differentiation
                                                     |__negative regulation of cartilage development
                                                     |   |__negative regulation of chondrocyte differentiation(+)
                                                     |__negative regulation of cell activation
                                                     |   |__negative regulation of astrocyte activation
                                                     |   |__negative regulation of endothelial cell activation
                                                     |   |__negative regulation of hepatic stellate cell activation
                                                     |   |__negative regulation of leukocyte activation(+)
                                                     |   |__negative regulation of platelet activation(+)
                                                     |   |__negative regulation of skeletal muscle satellite cell activation involved in skeletal muscle regeneration
                                                     |__negative regulation of chitin-based cuticle tanning
                                                     |   |__negative regulation of adult chitin-containing cuticle pigmentation
                                                     |__negative regulation of coagulation
                                                     |   |__negative regulation of blood coagulation(+)
                                                     |__negative regulation of cold-induced thermogenesis
                                                     |__negative regulation of collecting lymphatic vessel constriction
                                                     |__negative regulation of corticotropin secretion 1 rec.
                                                     |__negative regulation of cuticle pigmentation
                                                     |   |__negative regulation of adult chitin-containing cuticle pigmentation
                                                     |__negative regulation of cytokine production 2 rec.
                                                     |   |__negative regulation of chemokine production(+)
                                                     |   |__negative regulation of connective tissue growth factor production
                                                     |   |__negative regulation of cytokine production involved in immune response(+) 1 rec.
                                                     |   |__negative regulation of cytokine production involved in inflammatory response
                                                     |   |__negative regulation of endothelin production
                                                     |   |__negative regulation of fibroblast growth factor production
                                                     |   |__negative regulation of glial cell-derived neurotrophic factor production
                                                     |   |__negative regulation of granulocyte macrophage colony-stimulating factor production
                                                     |   |__negative regulation of hepatocyte growth factor production
                                                     |   |__negative regulation of interleukin-1 production(+)
                                                     |   |__negative regulation of interleukin-2 production
                                                     |   |__negative regulation of interleukin-3 production
                                                     |   |__negative regulation of interleukin-4 production
                                                     |   |__negative regulation of interleukin-5 production
                                                     |   |__negative regulation of interleukin-6 production
                                                     |   |__negative regulation of interleukin-7 production
                                                     |   |__negative regulation of interleukin-8 production
                                                     |   |__negative regulation of interleukin-9 production
                                                     |   |__negative regulation of interleukin-10 production
                                                     |   |__negative regulation of interleukin-11 production
                                                     |   |__negative regulation of interleukin-12 production
                                                     |   |__negative regulation of interleukin-13 production
                                                     |   |__negative regulation of interleukin-15 production
                                                     |   |__negative regulation of interleukin-16 production
                                                     |   |__negative regulation of interleukin-17 production(+)
                                                     |   |__negative regulation of interleukin-18 production
                                                     |   |__negative regulation of interleukin-19 production
                                                     |   |__negative regulation of interleukin-20 production
                                                     |   |__negative regulation of interleukin-21 production
                                                     |   |__negative regulation of interleukin-22 production
                                                     |   |__negative regulation of interleukin-23 production
                                                     |   |__negative regulation of interleukin-24 production
                                                     |   |__negative regulation of interleukin-25 production
                                                     |   |__negative regulation of interleukin-26 production
                                                     |   |__negative regulation of interleukin-27 production
                                                     |   |__negative regulation of interleukin-32 production
                                                     |   |__negative regulation of interleukin-33 production
                                                     |   |__negative regulation of interleukin-34 production
                                                     |   |__negative regulation of interleukin-35 production
                                                     |   |__negative regulation of interleukin-37 production
                                                     |   |__negative regulation of macrophage colony-stimulating factor production(+)
                                                     |   |__negative regulation of transforming growth factor beta production(+)
                                                     |   |__negative regulation of tumor necrosis factor superfamily cytokine production(+)
                                                     |   |__negative regulation of type I interferon production(+)
                                                     |   |__negative regulation of type II interferon production
                                                     |   |__negative regulation of type III interferon production
                                                     |   |__negative regulation of vascular endothelial growth factor production
                                                     |__negative regulation of determination of dorsal identity
                                                     |__negative regulation of digestive system process 1 rec.
                                                     |   |__negative regulation of defecation(+)
                                                     |   |__negative regulation of gastric acid secretion(+)
                                                     |   |__negative regulation of gastric emptying
                                                     |   |__negative regulation of hindgut contraction
                                                     |   |__negative regulation of intestinal absorption(+)
                                                     |   |__negative regulation of pancreatic juice secretion
                                                     |   |__negative regulation of saliva secretion
                                                     |   |__negative regulation of small intestinal transit
                                                     |__negative regulation of eclosion 1 rec.
                                                     |__negative regulation of embryo sac central cell differentiation
                                                     |__negative regulation of embryo sac egg cell differentiation
                                                     |__negative regulation of embryonic development
                                                     |   |__negative regulation of dermatome development
                                                     |   |__negative regulation of gastrulation
                                                     |__negative regulation of embryonic pattern specification
                                                     |__negative regulation of endothelial tube morphogenesis
                                                     |__negative regulation of epidermal growth factor receptor signaling pathway involved in heart process
                                                     |__negative regulation of epithelial cell migration 3 rec.
                                                     |   |__negative regulation of border follicle cell migration 2 rec.
                                                     |   |__negative regulation of keratinocyte migration
                                                     |__negative regulation of epithelial cell proliferation involved in prostate gland development
                                                     |__negative regulation of epithelial cell-cell adhesion involved in epithelium migration
                                                     |__negative regulation of epithelial to mesenchymal transition
                                                     |   |__negative regulation of cardiac epithelial to mesenchymal transition(+)
                                                     |   |__negative regulation of neural crest formation(+)
                                                     |__negative regulation of epithelial tube formation
                                                     |__negative regulation of fear response
                                                     |   |__negative regulation of behavioral fear response
                                                     |__negative regulation of female pigmentation
                                                     |__negative regulation of fusion cell fate specification 2 rec.
                                                     |__negative regulation of fusion of sperm to egg plasma membrane
                                                     |__negative regulation of germ cell proliferation 2 rec.
                                                     |   |__negative regulation of male germ cell proliferation 1 rec.
                                                     |__negative regulation of glomerular filtration
                                                     |__negative regulation of gonad development
                                                     |   |__negative regulation of female gonad development(+)
                                                     |   |__negative regulation of male gonad development
                                                     |__negative regulation of gonadotropin secretion
                                                     |   |__negative regulation of follicle-stimulating hormone secretion
                                                     |   |__negative regulation of luteinizing hormone secretion
                                                     |__negative regulation of hair cycle
                                                     |__negative regulation of hair follicle development
                                                     |   |__negative regulation of hair follicle maturation(+)
                                                     |   |__negative regulation of hair follicle placode formation
                                                     |__negative regulation of heat dissipation
                                                     |__negative regulation of heat generation
                                                     |   |__negative regulation of fever generation
                                                     |__negative regulation of hemopoiesis
                                                     |   |__negative regulation of hematopoietic stem cell proliferation
                                                     |   |__negative regulation of leukocyte differentiation(+)
                                                     |__negative regulation of hepatocyte differentiation
                                                     |__negative regulation of imaginal disc-derived wing vein specification 3 rec.
                                                     |__negative regulation of inhibin secretion
                                                     |__negative regulation of intestinal epithelial cell development
                                                     |__negative regulation of juvenile hormone secretion
                                                     |__negative regulation of keratinocyte differentiation
                                                     |__negative regulation of kidney development
                                                     |   |__negative regulation of glomerulus development(+)
                                                     |   |__negative regulation of mesonephros development(+)
                                                     |   |__negative regulation of metanephros development(+)
                                                     |   |__negative regulation of nephron tubule epithelial cell differentiation(+)
                                                     |__negative regulation of lactation
                                                     |__negative regulation of leaf development
                                                     |__negative regulation of lens epithelial cell proliferation
                                                     |__negative regulation of lens fiber cell differentiation
                                                     |__negative regulation of leukotriene production involved in inflammatory response
                                                     |__negative regulation of lipoprotein particle clearance
                                                     |   |__negative regulation of high-density lipoprotein particle clearance
                                                     |   |__negative regulation of low-density lipoprotein particle clearance
                                                     |   |__negative regulation of very-low-density lipoprotein particle clearance
                                                     |__negative regulation of lung alveolus development
                                                     |__negative regulation of lung ciliated cell differentiation
                                                     |__negative regulation of lung goblet cell differentiation
                                                     |__negative regulation of male germ-line stem cell asymmetric division
                                                     |__negative regulation of male pigmentation 1 rec.
                                                     |__negative regulation of mammary gland epithelial cell proliferation
                                                     |__negative regulation of mammary stem cell proliferation
                                                     |__negative regulation of maternal process involved in parturition
                                                     |__negative regulation of mesenchymal cell proliferation involved in lung development
                                                     |__negative regulation of mesenchymal cell proliferation involved in ureter development
                                                     |__negative regulation of mucus secretion
                                                     |__negative regulation of multicellular organism growth 13 rec.
                                                     |__negative regulation of muscle adaptation
                                                     |   |__negative regulation of cardiac muscle adaptation(+)
                                                     |   |__negative regulation of muscle atrophy
                                                     |   |__negative regulation of muscle hyperplasia
                                                     |   |__negative regulation of skeletal muscle hypertrophy
                                                     |   |__negative regulation of smooth muscle hypertrophy
                                                     |__negative regulation of muscle contraction 1 rec.
                                                     |   |__negative regulation of muscle filament sliding
                                                     |   |__negative regulation of smooth muscle contraction(+) 1 rec.
                                                     |   |__negative regulation of striated muscle contraction(+)
                                                     |__negative regulation of muscle hypertrophy
                                                     |   |__negative regulation of cardiac muscle hypertrophy(+)
                                                     |   |__negative regulation of skeletal muscle hypertrophy
                                                     |   |__negative regulation of smooth muscle hypertrophy
                                                     |__negative regulation of muscle organ development 5 rec.
                                                     |   |__negative regulation of somitomeric trunk muscle development
                                                     |   |__negative regulation of striated muscle tissue development(+) 1 rec.
                                                     |__negative regulation of nematode male tail tip morphogenesis
                                                     |__negative regulation of nervous system development 85 rec.
                                                     |   |__negative regulation of anterior neural cell fate commitment of the neural plate(+)
                                                     |   |__negative regulation of neurogenesis(+) 41 rec.
                                                     |   |__negative regulation of synapse assembly(+) 45 rec.
                                                     |__negative regulation of nervous system process 4 rec.
                                                     |   |__negative regulation of detection of mechanical stimulus involved in sensory perception of touch
                                                     |   |__negative regulation of myelination
                                                     |   |__negative regulation of sensory perception of bitter taste
                                                     |   |__negative regulation of sensory perception of pain 1 rec.
                                                     |   |__negative regulation of sensory perception of sweet taste
                                                     |   |__negative regulation of transmission of nerve impulse(+) 3 rec.
                                                     |__negative regulation of neural crest cell differentiation
                                                     |   |__negative regulation of neural crest cell fate specification
                                                     |__negative regulation of neurotrophin production
                                                     |   |__negative regulation of nerve growth factor production
                                                     |__negative regulation of oogenesis
                                                     |__negative regulation of organ growth 19 rec.
                                                     |   |__negative regulation of growth plate cartilage chondrocyte proliferation
                                                     |   |__negative regulation of heart growth(+)
                                                     |__negative regulation of ossification
                                                     |   |__negative regulation of bone mineralization(+)
                                                     |__negative regulation of ovulation
                                                     |__negative regulation of pancreatic A cell differentiation
                                                     |__negative regulation of parathyroid hormone secretion
                                                     |__negative regulation of penile erection
                                                     |__negative regulation of photoreceptor cell differentiation 13 rec.
                                                     |   |__negative regulation of compound eye photoreceptor cell differentiation(+) 9 rec.
                                                     |   |__negative regulation of retinal cone cell fate commitment(+)
                                                     |__negative regulation of plant organ morphogenesis
                                                     |__negative regulation of plasma lipoprotein oxidation
                                                     |__negative regulation of post-embryonic development 2 rec.
                                                     |   |__negative regulation of flower development
                                                     |   |__negative regulation of lateral root development
                                                     |   |__negative regulation of long-day photoperiodism, flowering
                                                     |   |__negative regulation of nematode larval development(+)
                                                     |   |__negative regulation of photomorphogenesis
                                                     |   |__negative regulation of pupariation 2 rec.
                                                     |   |__negative regulation of seed germination
                                                     |   |__negative regulation of short-day photoperiodism, flowering
                                                     |   |__negative regulation of stomatal complex development
                                                     |   |__negative regulation of thermomorphogenesis
                                                     |__negative regulation of relaxation of muscle
                                                     |   |__negative regulation of relaxation of cardiac muscle
                                                     |   |__negative regulation of relaxation of smooth muscle(+)
                                                     |__negative regulation of renal albumin absorption
                                                     |__negative regulation of renal amino acid absorption
                                                     |__negative regulation of renal phosphate excretion
                                                     |__negative regulation of renal sodium excretion
                                                     |   |__negative regulation of renal sodium excretion by angiotensin
                                                     |__negative regulation of renal water transport
                                                     |__negative regulation of respiratory burst involved in inflammatory response
                                                     |__negative regulation of respiratory gaseous exchange
                                                     |__negative regulation of retina development in camera-type eye
                                                     |   |__negative regulation of neural retina development
                                                     |__negative regulation of salivary gland boundary specification 8 rec.
                                                     |   |__negative regulation of adult salivary gland boundary specification
                                                     |   |__negative regulation of larval salivary gland boundary specification
                                                     |__negative regulation of seed dormancy process
                                                     |__negative regulation of seed maturation
                                                     |__negative regulation of sperm capacitation
                                                     |__negative regulation of spermatid nuclear differentiation
                                                     |__negative regulation of spore-bearing organ development
                                                     |   |__negative regulation of aecium development
                                                     |   |__negative regulation of ascus development
                                                     |   |__negative regulation of basidium development
                                                     |   |__negative regulation of conidiophore development(+)
                                                     |   |__negative regulation of oogonium development
                                                     |   |__negative regulation of sorocarp stalk cell differentiation
                                                     |   |__negative regulation of sporangium development(+)
                                                     |   |__negative regulation of sporocarp development involved in sexual reproduction(+)
                                                     |   |__negative regulation of telium development
                                                     |   |__negative regulation of uredinium development
                                                     |   |__negative regulation of zygosporangium development
                                                     |__negative regulation of stem cell population maintenance
                                                     |   |__negative regulation of somatic stem cell population maintenance(+)
                                                     |__negative regulation of steroid hormone secretion
                                                     |   |__negative regulation of androgen secretion
                                                     |   |__negative regulation of corticosteroid hormone secretion(+)
                                                     |   |__negative regulation of ecdysteroid secretion
                                                     |   |__negative regulation of estradiol secretion
                                                     |   |__negative regulation of estrogen secretion
                                                     |   |__negative regulation of estrone secretion
                                                     |   |__negative regulation of progesterone secretion
                                                     |__negative regulation of synergid differentiation
                                                     |__negative regulation of terminal cell fate specification, open tracheal system 3 rec.
                                                     |__negative regulation of thyroid gland epithelial cell proliferation
                                                     |__negative regulation of tissue remodeling
                                                     |   |__negative regulation of blood vessel remodeling(+)
                                                     |   |__negative regulation of bone remodeling(+)
                                                     |   |__negative regulation of connective tissue replacement(+)
                                                     |   |__negative regulation of erythrocyte clearance
                                                     |   |__negative regulation of mammary gland involution
                                                     |__negative regulation of tolerance induction
                                                     |   |__negative regulation of B cell tolerance induction(+)
                                                     |   |__negative regulation of central tolerance induction(+)
                                                     |   |__negative regulation of lymphocyte anergy(+)
                                                     |   |__negative regulation of natural killer cell tolerance induction
                                                     |   |__negative regulation of T cell tolerance induction(+)
                                                     |   |__negative regulation of tolerance induction dependent upon immune response(+)
                                                     |   |__negative regulation of tolerance induction to self antigen
                                                     |__negative regulation of transcytosis
                                                     |__negative regulation of transport across blood-brain barrier
                                                     |   |__negative regulation of lipid transport across blood-brain barrier
                                                     |__negative regulation of trichome patterning
                                                     |__negative regulation of trophoblast cell migration
                                                     |__negative regulation of tube lumen cavitation
                                                     |__negative regulation of type B pancreatic cell development
                                                     |__negative regulation of ureter smooth muscle cell differentiation
                                                     |__negative regulation of vasculature development
                                                     |   |__negative regulation of blood vessel morphogenesis(+)
                                                     |   |__negative regulation of vasculature development involved in avascular cornea development in camera-type eye
                                                     |__negative regulation of vasoconstriction
                                                     |   |__negative regulation of vascular associated smooth muscle contraction(+)
                                                     |__negative regulation of very-low-density lipoprotein particle remodeling
                                                     |__negative regulation of vitellogenesis
                                                     |__negative regulation of Wnt signaling pathway involved in heart development
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Is a negative regulation of biological process
regulation of multicellular organismal process
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Synonyms
  • "down regulation of multicellular organismal process" EXACT
    "down-regulation of multicellular organismal process" EXACT
    "downregulation of multicellular organismal process" EXACT
    "inhibition of multicellular organismal process" NARROW
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