FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term negative regulation of protein metabolic process ID (Ontology) GO:0051248 (Gene Ontology)
Definition Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein.
Also Known As "down regulation of cellular protein metabolic process" ; "down regulation of protein metabolic process" ; "down-regulation of cellular protein metabolic process" (for all, see Synonyms field below)
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negative regulation of metabolic process
 |__negative regulation of macromolecule metabolic process__
regulation of macromolecule metabolic process               |
 |__negative regulation of macromolecule metabolic process__|
 |__regulation of protein metabolic process_________________|
regulation of primary metabolic process                     |
 |__regulation of protein metabolic process_________________|
                                                            negative regulation of protein metabolic process  140 rec.
                                                             |__negative regulation of amyloid fibril formation
                                                             |__negative regulation of amyloid precursor protein catabolic process
                                                             |   |__negative regulation of amyloid-beta formation
                                                             |__negative regulation of glycoprotein metabolic process 1 rec.
                                                             |   |__negative regulation by host of viral glycoprotein metabolic process
                                                             |   |__negative regulation of elastin catabolic process
                                                             |   |__negative regulation of glycoprotein biosynthetic process(+) 1 rec.
                                                             |__negative regulation of granulocyte macrophage colony-stimulating factor production
                                                             |__negative regulation of hemoglobin biosynthetic process
                                                             |__negative regulation of hepatocyte growth factor production
                                                             |__negative regulation of lipoprotein metabolic process
                                                             |   |__negative regulation of lipoprotein oxidation(+)
                                                             |   |__negative regulation of protein lipidation(+)
                                                             |__negative regulation of lymphotoxin A production
                                                             |__negative regulation of protein catabolic process 18 rec.
                                                             |   |__negative regulation of chaperone-mediated autophagy
                                                             |   |__negative regulation of elastin catabolic process
                                                             |   |__negative regulation of low-density lipoprotein particle receptor catabolic process
                                                             |   |__negative regulation of membrane protein ectodomain proteolysis 1 rec.
                                                             |   |__negative regulation of proteasomal protein catabolic process(+) 15 rec.
                                                             |   |__negative regulation of protein catabolic process in the vacuole(+) 1 rec.
                                                             |   |__negative regulation of proteolysis associated with antigen processing and presentation
                                                             |__negative regulation of protein maturation 6 rec.
                                                             |   |__negative regulation of N-terminal peptidyl-lysine acetylation
                                                             |   |__negative regulation of N-terminal peptidyl-methionine acetylation
                                                             |   |__negative regulation of protein activation cascade(+) 5 rec.
                                                             |   |__negative regulation of protein processing(+) 1 rec.
                                                             |__negative regulation of protein modification process 8 rec.
                                                             |   |__negative regulation of peptidyl-cysteine S-nitrosylation
                                                             |   |__negative regulation of peptidyl-lysine crotonylation
                                                             |   |__negative regulation of post-translational protein modification(+) 7 rec.
                                                             |   |__negative regulation of protein acetylation(+)
                                                             |   |__negative regulation of protein adenylylation
                                                             |   |__negative regulation of protein geranylgeranylation
                                                             |   |__negative regulation of protein glutathionylation
                                                             |   |__negative regulation of protein lipidation(+)
                                                             |   |__negative regulation of protein oxidation
                                                             |   |__negative regulation of protein phosphorylation(+) 1 rec.
                                                             |   |__negative regulation of protein polyglycylation
                                                             |   |__negative regulation of protein-pyridoxal-5-phosphate linkage
                                                             |   |__negative regulation of tubulin deacetylation
                                                             |__negative regulation of proteolysis 44 rec.
                                                             |   |__negative regulation of membrane protein ectodomain proteolysis 1 rec.
                                                             |   |__negative regulation of peptidase activity(+)
                                                             |   |__negative regulation of protein processing(+) 1 rec.
                                                             |   |__negative regulation of proteolysis involved in protein catabolic process(+) 20 rec.
                                                             |__negative regulation of translation 85 rec.
                                                                 |__miRNA-mediated gene silencing by inhibition of translation 15 rec.
                                                                 |__negative regulation of cytoplasmic translation(+) 5 rec.
                                                                 |__negative regulation of mitochondrial translation(+)
                                                                 |__negative regulation of oskar mRNA translation 9 rec.
                                                                 |__negative regulation of translation in response to stress(+)
                                                                 |__negative regulation of translational elongation(+) 2 rec.
                                                                 |__negative regulation of translational fidelity
                                                                 |__negative regulation of translational initiation(+) 14 rec.
                                                                 |__negative regulation of translational termination
                                                                 |__ribosome hibernation 1 rec.
                                                                 |__siRNA-mediated gene silencing by inhibition of translation
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Is a negative regulation of macromolecule metabolic process
regulation of protein metabolic process
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Synonyms
  • "down regulation of cellular protein metabolic process" EXACT
    "down regulation of protein metabolic process" EXACT
    "down-regulation of cellular protein metabolic process" EXACT
    "down-regulation of protein metabolic process" EXACT
    "downregulation of cellular protein metabolic process" EXACT
    "downregulation of protein metabolic process" EXACT
    "inhibition of cellular protein metabolic process" NARROW
    "inhibition of protein metabolic process" NARROW
    "negative regulation of cellular protein metabolic process" EXACT
    "negative regulation of cellular protein metabolism" EXACT
    "negative regulation of protein metabolism" EXACT
Secondary IDs
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