FB2025_05 , released December 11, 2025
FB2025_05 , released December 11, 2025
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Term regulation of small molecule metabolic process ID (Ontology) GO:0062012 (Gene Ontology)
Definition Any process that modulates the rate, frequency or extent of a small molecule metabolic process.
Also Known As "regulation of small molecule metabolism"
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  regulation of cellular process
   |__regulation of metabolic process
       |__regulation of small molecule metabolic process  49 rec.
           |__negative regulation of small molecule metabolic process 4 rec.
           |   |__negative regulation of (R)-mevalonic acid biosynthetic process
           |   |__negative regulation of acetate catabolic process
           |   |__negative regulation of aflatoxin biosynthetic process
           |   |__negative regulation of alcohol biosynthetic process(+)
           |   |__negative regulation of alcohol catabolic process
           |   |__negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity
           |   |__negative regulation of androst-4-ene-3,17-dione biosynthetic process
           |   |__negative regulation of arginine catabolic process
           |   |__negative regulation of asperthecin biosynthetic process
           |   |__negative regulation of bile acid biosynthetic process
           |   |__negative regulation of cholesterol metabolic process(+)
           |   |__negative regulation of citrulline biosynthetic process
           |   |__negative regulation of ecdysteroid biosynthetic process
           |   |__negative regulation of emericellamide biosynthetic process(+)
           |   |__negative regulation of emodin biosynthetic process
           |   |__negative regulation of endocrocin biosynthetic process
           |   |__negative regulation of fatty acid metabolic process(+) 2 rec.
           |   |__negative regulation of ferulate catabolic process
           |   |__negative regulation of fumagillin biosynthetic process
           |   |__negative regulation of fumonisin biosynthetic process
           |   |__negative regulation of gamma-aminobutyric acid catabolic process
           |   |__negative regulation of gerfelin biosynthetic process
           |   |__negative regulation of gibberellin biosynthetic process
           |   |__negative regulation of gluconeogenesis
           |   |__negative regulation of glucose catabolic process to lactate via pyruvate
           |   |__negative regulation of glutamate metabolic process(+)
           |   |__negative regulation of glycolytic fermentation to ethanol
           |   |__negative regulation of glyoxylate cycle
           |   |__negative regulation of helvolic acid biosynthetic process
           |   |__negative regulation of histidine biosynthetic process
           |   |__negative regulation of homoserine biosynthetic process
           |   |__negative regulation of indoleacetic acid biosynthetic process via tryptophan
           |   |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
           |   |__negative regulation of L-dopa biosynthetic process
           |   |__negative regulation of L-glutamine biosynthetic process
           |   |__negative regulation of L-leucine biosynthetic process
           |   |__negative regulation of L-proline biosynthetic process
           |   |__negative regulation of lysine biosynthetic process via aminoadipic acid(+)
           |   |__negative regulation of methane biosynthetic process from formic acid
           |   |__negative regulation of monodictyphenone biosynthetic process
           |   |__negative regulation of naphtho-gamma-pyrone biosynthetic process
           |   |__negative regulation of nucleoside metabolic process
           |   |__negative regulation of nucleotide metabolic process(+) 1 rec.
           |   |__negative regulation of o-orsellinic acid biosynthetic process
           |   |__negative regulation of ornithine catabolic process
           |   |__negative regulation of penicillin biosynthetic process
           |   |__negative regulation of penicillin catabolic process
           |   |__negative regulation of progesterone biosynthetic process(+)
           |   |__negative regulation of pseurotin A biosynthetic process
           |   |__negative regulation of purine nucleobase metabolic process
           |   |__negative regulation of pyrimidine nucleobase metabolic process
           |   |__negative regulation of pyruvate decarboxylation to acetyl-CoA
           |   |__negative regulation of quinolinate biosynthetic process
           |   |__negative regulation of sarcinapterin biosynthetic process
           |   |__negative regulation of tatiopterin biosynthetic process
           |   |__negative regulation of tensidol A biosynthetic process
           |   |__negative regulation of tensidol B biosynthetic process
           |   |__negative regulation of testosterone biosynthetic process
           |   |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
           |   |__negative regulation of ubiquinone biosynthetic process
           |   |__negative regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
           |   |__negative regulation of urea catabolic process
           |   |__negative regulation of vitamin metabolic process(+)
           |   |__negative regulation of xanthone-containing compound biosynthetic process(+)
           |   |__negative regulation of xylose catabolic process to ethanol
           |__positive regulation of small molecule metabolic process 33 rec.
           |   |__positive regulation of (R)-mevalonic acid biosynthetic process
           |   |__positive regulation of acetate catabolic process
           |   |__positive regulation of aflatoxin biosynthetic process
           |   |__positive regulation of alcohol biosynthetic process(+)
           |   |__positive regulation of alcohol catabolic process(+)
           |   |__positive regulation of ammonia assimilation cycle
           |   |__positive regulation of androst-4-ene-3,17-dione biosynthetic process
           |   |__positive regulation of arginine biosynthetic process
           |   |__positive regulation of asperthecin biosynthetic process
           |   |__positive regulation of bile acid biosynthetic process
           |   |__positive regulation of cholesterol metabolic process(+)
           |   |__positive regulation of citrulline biosynthetic process
           |   |__positive regulation of ecdysteroid biosynthetic process 6 rec.
           |   |__positive regulation of emericellamide biosynthetic process(+)
           |   |__positive regulation of emodin biosynthetic process
           |   |__positive regulation of endocrocin biosynthetic process
           |   |__positive regulation of fatty acid metabolic process(+)
           |   |__positive regulation of ferulate catabolic process
           |   |__positive regulation of fumagillin biosynthetic process
           |   |__positive regulation of fumonisin biosynthetic process
           |   |__positive regulation of gamma-aminobutyric acid catabolic process
           |   |__positive regulation of gerfelin biosynthetic process
           |   |__positive regulation of gibberellin biosynthetic process
           |   |__positive regulation of glucose metabolic process(+) 16 rec.
           |   |__positive regulation of glycolytic fermentation to ethanol
           |   |__positive regulation of glyoxylate cycle
           |   |__positive regulation of helvolic acid biosynthetic process
           |   |__positive regulation of histidine biosynthetic process
           |   |__positive regulation of homoserine biosynthetic process
           |   |__positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
           |   |__positive regulation of L-dopa biosynthetic process
           |   |__positive regulation of L-glutamine biosynthetic process
           |   |__positive regulation of L-leucine biosynthetic process
           |   |__positive regulation of L-proline catabolic process to L-glutamate
           |   |__positive regulation of L-tryptophan metabolic process(+)
           |   |__positive regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine
           |   |__positive regulation of methane biosynthetic process from formic acid
           |   |__positive regulation of monodictyphenone biosynthetic process
           |   |__positive regulation of N-acetylmuramic acid catabolic process
           |   |__positive regulation of naphtho-gamma-pyrone biosynthetic process
           |   |__positive regulation of nucleoside metabolic process
           |   |__positive regulation of nucleotide metabolic process(+) 6 rec.
           |   |__positive regulation of o-orsellinic acid biosynthetic process
           |   |__positive regulation of ornithine catabolic process
           |   |__positive regulation of penicillin metabolic process(+)
           |   |__positive regulation of progesterone biosynthetic process
           |   |__positive regulation of pseurotin A biosynthetic process
           |   |__positive regulation of purine nucleobase metabolic process
           |   |__positive regulation of pyrimidine nucleobase metabolic process
           |   |__positive regulation of pyruvate decarboxylation to acetyl-CoA 2 rec.
           |   |__positive regulation of quinolinate biosynthetic process
           |   |__positive regulation of sarcinapterin biosynthetic process
           |   |__positive regulation of tatiopterin biosynthetic process
           |   |__positive regulation of taurine biosynthetic process
           |   |__positive regulation of tensidol A biosynthetic process
           |   |__positive regulation of tensidol B biosynthetic process
           |   |__positive regulation of terrequinone A biosynthetic process
           |   |__positive regulation of tetrapyrrole biosynthetic process from glutamate
           |   |__positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
           |   |__positive regulation of ubiquinone biosynthetic process 3 rec.
           |   |__positive regulation of UDP-N-acetylglucosamine biosynthetic process
           |   |__positive regulation of urea catabolic process
           |   |__positive regulation of vitamin metabolic process(+)
           |   |__positive regulation of xanthone-containing compound biosynthetic process(+)
           |   |__positive regulation of xylose catabolic process to ethanol
           |__regulation of (R)-mevalonic acid biosynthetic process
           |   |__negative regulation of (R)-mevalonic acid biosynthetic process
           |   |__positive regulation of (R)-mevalonic acid biosynthetic process
           |__regulation of 1-aminocyclopropane-1-carboxylate metabolic process
           |__regulation of acetate catabolic process
           |   |__negative regulation of acetate catabolic process
           |   |__positive regulation of acetate catabolic process
           |__regulation of aflatoxin biosynthetic process
           |   |__negative regulation of aflatoxin biosynthetic process
           |   |__positive regulation of aflatoxin biosynthetic process
           |__regulation of alcohol biosynthetic process 1 rec.
           |   |__negative regulation of alcohol biosynthetic process(+)
           |   |__positive regulation of alcohol biosynthetic process(+)
           |   |__regulation of abscisic acid biosynthetic process(+)
           |   |__regulation of aldosterone biosynthetic process(+)
           |   |__regulation of asperfuranone biosynthetic process(+)
           |   |__regulation of butyryl-CoA catabolic process to butanol(+)
           |   |__regulation of cholesterol biosynthetic process(+) 1 rec.
           |   |__regulation of cortisol biosynthetic process(+)
           |   |__regulation of ergosterol biosynthetic process(+)
           |   |__regulation of inositol biosynthetic process(+)
           |   |__regulation of inositol phosphate biosynthetic process(+)
           |   |__regulation of kojic acid biosynthetic process(+)
           |   |__regulation of neosartoricin biosynthetic process(+)
           |   |__regulation of phytol biosynthetic process(+)
           |   |__regulation of thiamine biosynthetic process(+)
           |__regulation of alcohol catabolic process
           |   |__negative regulation of alcohol catabolic process
           |   |__positive regulation of alcohol catabolic process(+)
           |   |__regulation of ethanol catabolic process(+)
           |__regulation of aldosterone metabolic process
           |   |__regulation of aldosterone biosynthetic process(+)
           |__regulation of arginine biosynthetic process
           |   |__positive regulation of arginine biosynthetic process
           |   |__regulation of arginine biosynthetic process via ornithine
           |__regulation of arginine catabolic process
           |   |__negative regulation of arginine catabolic process
           |__regulation of bile acid biosynthetic process
           |   |__negative regulation of bile acid biosynthetic process
           |   |__positive regulation of bile acid biosynthetic process
           |__regulation of cholesterol metabolic process 1 rec.
           |   |__negative regulation of cholesterol metabolic process(+)
           |   |__positive regulation of cholesterol metabolic process(+)
           |   |__regulation of cholesterol biosynthetic process(+) 1 rec.
           |__regulation of citrulline biosynthetic process
           |   |__negative regulation of citrulline biosynthetic process
           |   |__positive regulation of citrulline biosynthetic process
           |__regulation of coenzyme A biosynthetic process
           |__regulation of cysteine metabolic process
           |__regulation of D-xylose catabolic process
           |   |__regulation of xylose catabolic process to ethanol(+)
           |__regulation of emericellamide biosynthetic process
           |   |__negative regulation of emericellamide biosynthetic process(+)
           |   |__positive regulation of emericellamide biosynthetic process(+)
           |   |__regulation of emericellamide A biosynthetic process(+)
           |__regulation of fatty acid metabolic process 7 rec.
           |   |__negative regulation of fatty acid metabolic process(+) 2 rec.
           |   |__positive regulation of fatty acid metabolic process(+)
           |   |__regulation of acyl-CoA biosynthetic process(+) 3 rec.
           |   |__regulation of butyryl-CoA catabolic process to butanol(+)
           |   |__regulation of fatty acid biosynthetic process(+) 2 rec.
           |   |__regulation of fatty acid oxidation(+) 1 rec.
           |   |__regulation of jasmonic acid metabolic process(+)
           |   |__regulation of methane biosynthetic process from 3-(methylthio)propionic acid(+)
           |   |__regulation of palmitic acid catabolic process(+)
           |__regulation of ferulate catabolic process
           |   |__negative regulation of ferulate catabolic process
           |   |__positive regulation of ferulate catabolic process
           |__regulation of fucose catabolic process
           |__regulation of fumagillin biosynthetic process
           |   |__negative regulation of fumagillin biosynthetic process
           |   |__positive regulation of fumagillin biosynthetic process
           |__regulation of fumonisin biosynthetic process
           |   |__negative regulation of fumonisin biosynthetic process
           |   |__positive regulation of fumonisin biosynthetic process
           |__regulation of gamma-aminobutyric acid catabolic process
           |   |__negative regulation of gamma-aminobutyric acid catabolic process
           |   |__positive regulation of gamma-aminobutyric acid catabolic process
           |__regulation of gerfelin biosynthetic process
           |   |__negative regulation of gerfelin biosynthetic process
           |   |__positive regulation of gerfelin biosynthetic process
           |__regulation of gibberellin biosynthetic process
           |   |__negative regulation of gibberellin biosynthetic process
           |   |__positive regulation of gibberellin biosynthetic process
           |__regulation of glucose metabolic process 19 rec.
           |   |__positive regulation of glucose metabolic process(+) 16 rec.
           |   |__regulation of gluconeogenesis(+) 3 rec.
           |   |__regulation of glucose catabolic process to lactate via pyruvate(+)
           |__regulation of glucosinolate biosynthetic process
           |__regulation of glutamate metabolic process 1 rec.
           |   |__negative regulation of glutamate metabolic process(+)
           |   |__regulation of ammonia assimilation cycle(+)
           |   |__regulation of L-proline catabolic process to L-glutamate(+)
           |   |__regulation of tetrapyrrole biosynthetic process from glutamate(+)
           |__regulation of glycolytic fermentation to ethanol
           |   |__negative regulation of glycolytic fermentation to ethanol
           |   |__positive regulation of glycolytic fermentation to ethanol
           |__regulation of glyoxylate cycle
           |   |__negative regulation of glyoxylate cycle
           |   |__positive regulation of glyoxylate cycle
           |__regulation of histidine biosynthetic process
           |   |__negative regulation of histidine biosynthetic process
           |   |__positive regulation of histidine biosynthetic process
           |__regulation of homoserine biosynthetic process
           |   |__negative regulation of homoserine biosynthetic process
           |   |__positive regulation of homoserine biosynthetic process
           |__regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
           |   |__negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
           |   |__positive regulation of isopentenyl diphosphate biosynthetic process, mevalonate pathway
           |__regulation of ketone biosynthetic process 9 rec.
           |   |__positive regulation of terrequinone A biosynthetic process
           |   |__regulation of aldosterone biosynthetic process(+)
           |   |__regulation of androst-4-ene-3,17-dione biosynthetic process(+)
           |   |__regulation of asperthecin biosynthetic process(+)
           |   |__regulation of cortisol biosynthetic process(+)
           |   |__regulation of ecdysteroid biosynthetic process(+) 6 rec.
           |   |__regulation of emodin biosynthetic process(+)
           |   |__regulation of endocrocin biosynthetic process(+)
           |   |__regulation of helvolic acid biosynthetic process(+)
           |   |__regulation of kojic acid biosynthetic process(+)
           |   |__regulation of monodictyphenone biosynthetic process(+)
           |   |__regulation of naphtho-gamma-pyrone biosynthetic process(+)
           |   |__regulation of polyketide biosynthetic process(+)
           |   |__regulation of progesterone biosynthetic process(+)
           |   |__regulation of tensidol A biosynthetic process(+)
           |   |__regulation of tensidol B biosynthetic process(+)
           |   |__regulation of testosterone biosynthetic process(+)
           |   |__regulation of ubiquinone biosynthetic process(+) 3 rec.
           |   |__regulation of xanthone-containing compound biosynthetic process(+)
           |__regulation of ketone catabolic process
           |__regulation of L-dopa biosynthetic process
           |   |__negative regulation of L-dopa biosynthetic process
           |   |__positive regulation of L-dopa biosynthetic process
           |__regulation of L-glutamine biosynthetic process 1 rec.
           |   |__negative regulation of L-glutamine biosynthetic process
           |   |__positive regulation of L-glutamine biosynthetic process
           |__regulation of L-leucine biosynthetic process
           |   |__negative regulation of L-leucine biosynthetic process
           |   |__positive regulation of L-leucine biosynthetic process
           |__regulation of L-proline metabolic process
           |   |__regulation of L-proline biosynthetic process(+)
           |   |__regulation of L-proline catabolic process to L-glutamate(+)
           |__regulation of L-tryptophan metabolic process
           |   |__positive regulation of L-tryptophan metabolic process(+)
           |   |__regulation of 'de novo' NAD biosynthetic process from L-tryptophan(+)
           |   |__regulation of indoleacetic acid biosynthetic process via tryptophan(+)
           |__regulation of lysine biosynthetic process via aminoadipic acid
           |   |__negative regulation of lysine biosynthetic process via aminoadipic acid(+)
           |   |__regulation of lysine biosynthetic process via alpha-aminoadipate and saccharopine(+)
           |__regulation of methane biosynthetic process from formic acid
           |   |__negative regulation of methane biosynthetic process from formic acid
           |   |__positive regulation of methane biosynthetic process from formic acid
           |__regulation of nitrate assimilation
           |__regulation of nucleoside metabolic process
           |   |__negative regulation of nucleoside metabolic process
           |   |__positive regulation of nucleoside metabolic process
           |__regulation of nucleotide metabolic process 12 rec.
           |   |__negative regulation of nucleotide metabolic process(+) 1 rec.
           |   |__positive regulation of nucleotide metabolic process(+) 6 rec.
           |   |__regulation of nucleotide biosynthetic process(+) 3 rec.
           |   |__regulation of nucleotide catabolic process(+) 8 rec.
           |   |__regulation of purine nucleotide metabolic process(+) 12 rec.
           |__regulation of o-orsellinic acid biosynthetic process
           |   |__negative regulation of o-orsellinic acid biosynthetic process
           |   |__positive regulation of o-orsellinic acid biosynthetic process
           |__regulation of ornithine metabolic process
           |   |__regulation of ornithine catabolic process(+)
           |__regulation of penicillin biosynthetic process
           |   |__negative regulation of penicillin biosynthetic process
           |   |__positive regulation of penicillin biosynthetic process
           |__regulation of penicillin catabolic process
           |   |__negative regulation of penicillin catabolic process
           |   |__positive regulation of penicillin catabolic process
           |__regulation of pseurotin A biosynthetic process
           |   |__negative regulation of pseurotin A biosynthetic process
           |   |__positive regulation of pseurotin A biosynthetic process
           |__regulation of purine nucleobase metabolic process
           |   |__negative regulation of purine nucleobase metabolic process
           |   |__positive regulation of purine nucleobase metabolic process
           |   |__regulation of adenine biosynthetic process
           |__regulation of quinolinate biosynthetic process
           |   |__negative regulation of quinolinate biosynthetic process
           |   |__positive regulation of quinolinate biosynthetic process
           |__regulation of rhamnose catabolic process
           |__regulation of salicylic acid metabolic process
           |   |__regulation of salicylic acid biosynthetic process
           |__regulation of sarcinapterin biosynthetic process
           |   |__negative regulation of sarcinapterin biosynthetic process
           |   |__positive regulation of sarcinapterin biosynthetic process
           |__regulation of tatiopterin biosynthetic process
           |   |__negative regulation of tatiopterin biosynthetic process
           |   |__positive regulation of tatiopterin biosynthetic process
           |__regulation of taurine biosynthetic process
           |   |__positive regulation of taurine biosynthetic process
           |__regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
           |   |__negative regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
           |   |__positive regulation of tetrapyrrole biosynthetic process from glycine and succinyl-CoA
           |__regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
           |   |__negative regulation of UDP-N-acetylglucosamine biosynthetic process 1 rec.
           |   |__positive regulation of UDP-N-acetylglucosamine biosynthetic process
           |__regulation of urea catabolic process
           |   |__negative regulation of urea catabolic process
           |   |__positive regulation of urea catabolic process
           |__regulation of vitamin metabolic process
               |__negative regulation of vitamin metabolic process(+)
               |__positive regulation of vitamin metabolic process(+)
               |__regulation of L-ascorbic acid biosynthetic process(+)
               |__regulation of retinoic acid biosynthetic process(+)
               |__regulation of thiamine biosynthetic process(+)
               |__regulation of thiamine diphosphate biosynthetic process(+)
               |__regulation of vitamin D biosynthetic process(+)
               |__regulation of vitamin E biosynthetic process(+)
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Is a regulation of metabolic process
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Synonyms
  • "regulation of small molecule metabolism" EXACT
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Reactome:R-HSA-9861718 "Regulation of pyruvate metabolism"