FB2025_05 , released December 11, 2025

CV Term Report

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General Information
Term	protein activation cascade	ID (Ontology)	GO:0072376 (Gene Ontology)
Definition	A sequential series of modifications to a set of proteins where the product of one reaction catalyzes the following reaction, ultimately leading to the generation of a mature protein. Modifications typically include proteolysis or covalent modification, and may also include binding events.
Also Known As	"protein activation pathway" ; "protein activitory cascade"
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Spanning Tree (Parents/Children)

  protein metabolic process
   |__protein maturation
       |__protein activation cascade  29 rec.
           |__blood coagulation, common pathway
           |__blood coagulation, extrinsic pathway
           |__blood coagulation, fibrin clot formation
           |__blood coagulation, intrinsic pathway
           |__kinin cascade
           |   |__plasma kallikrein-kinin cascade
           |   |__tissue kallikrein-kinin cascade
           |__Toll receptor ligand protein activation cascade 29 rec.

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Relationships
Is a	protein maturation
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Synonyms & Secondary IDs
Synonyms
	"protein activation pathway" EXACT "protein activitory cascade" EXACT
Secondary IDs

External Crossreferences & Linkouts