General Information
Term	gene silencing by siRNA-directed DNA methylation	ID (Ontology)	GO:0080188 (Gene Ontology)
Definition	A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.[ PubMed:21420348 PubMed:33031395 ]
Also Known As	"RdDM"
Comment
Links to External Ontologies
	QuickGO data AmiGO data
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Records annotated with this term OR any of its CHILD TERMS
No relevant records available
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

gene silencing by siRNA-directed DNA methylation

ID (Ontology)

GO:0080188 (Gene Ontology)

Definition

A small RNA-based gene silencing process in which small interfering RNAs (siRNAs) guide DNA methylation to the siRNA-generating genomic loci and other loci that are homologous to the siRNAs for de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription. In general this process consists of three phases: biogenesis of siRNAs, scaffold RNA production, and the formation of the guiding complex that recruits de novo DNA methyltransferases to the target loci. Transposable elements are silenced by this mechanism.[ PubMed:21420348 PubMed:33031395 ]

Also Known As

"RdDM"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

regulatory ncRNA-mediated heterochromatin formation
 |__siRNA-mediated heterochromatin formation__________________________
constitutive heterochromatin formation                                |
 |__DNA methylation-dependent constitutive heterochromatin formation__|
                                                                      gene silencing by siRNA-directed DNA methylation
                                                                       |__transposable element silencing by siRNA-mediated DNA methylation

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Is a	DNA methylation-dependent constitutive heterochromatin formation siRNA-mediated heterochromatin formation
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Synonyms & Secondary IDs
Synonyms
	"gene silencing by RNA-directed DNA methylation" RELATED "RdDM" EXACT "RNA-directed DNA methylation" RELATED
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Is a

DNA methylation-dependent constitutive heterochromatin formation
siRNA-mediated heterochromatin formation

Part of

Synonyms & Secondary IDs

Synonyms

"gene silencing by RNA-directed DNA methylation" RELATED
"RdDM" EXACT
"RNA-directed DNA methylation" RELATED

Secondary IDs

External Crossreferences & Linkouts