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| Term | gene silencing by piRNA-directed DNA methylation | ID (Ontology) | GO:0141176 (Gene Ontology) |
| Definition | A small RNA-based gene silencing process in which Piwi-associated RNAs (piRNAs) guide de novo DNA methylation. This results in a heterochromatin assembly, a chromatin conformation that is refractory to transcription.[ PubMed:32674113 PubMed:38359823 ] | ||
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regulatory ncRNA-mediated heterochromatin formation |__piRNA-mediated heterochromatin formation__________________________ constitutive heterochromatin formation | |__DNA methylation-dependent constitutive heterochromatin formation__| gene silencing by piRNA-directed DNA methylation |__transposable element silencing by piRNA-mediated DNA methylation |
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DNA methylation-dependent constitutive heterochromatin formation piRNA-mediated heterochromatin formation |
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