General Information
Term	cis_regulatory_module	ID (Ontology)	SO:0000727 (Sequence Ontology)
Definition	A regulatory region where transcription factor binding sites are clustered to regulate various aspects of transcription activities. (CRMs can be located a few kb to hundreds of kb upstream of the core promoter, in the coding sequence, within introns, or in the untranslated regions (UTR) sequences, and even on a different chromosome). A single gene can be regulated by multiple CRMs to give precise control of its spatial and temporal expression. CRMs function as nodes in large, intertwined regulatory network. CRM DNA accessibility is subject to regulation by dbTFs and transcription co-TFs.[ PubMed:19660565 ]
Also Known As	"cis regulatory module" ; "CRM" ; "TF module" (for all, see Synonyms field below)
Comment
Links to External Ontologies
	SO.org
Annotations
Records annotated with this term OR any of its CHILD TERMS
Results list data from multiple species. Click on a button above and use the 'Filter by species' options on the resulting HitList to retrieve species-specific data.
Records annotated with this exact term (annotations to child terms are NOT included)
No relevant records available
Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
No relevant statements available

General Information

Term

cis_regulatory_module

ID (Ontology)

SO:0000727 (Sequence Ontology)

Definition

A regulatory region where transcription factor binding sites are clustered to regulate various aspects of transcription activities. (CRMs can be located a few kb to hundreds of kb upstream of the core promoter, in the coding sequence, within introns, or in the untranslated regions (UTR) sequences, and even on a different chromosome). A single gene can be regulated by multiple CRMs to give precise control of its spatial and temporal expression. CRMs function as nodes in large, intertwined regulatory network. CRM DNA accessibility is subject to regulation by dbTFs and transcription co-TFs.[ PubMed:19660565 ]

Also Known As

"cis regulatory module" ; "CRM" ; "TF module" (for all, see Synonyms field below)

Comment

Links to External Ontologies

SO.org

Annotations

Records annotated with this term OR any of its CHILD TERMS

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

No relevant statements available

  regulatory_region
   |__transcriptional_cis_regulatory_region
       |__cis_regulatory_module  248446 rec.
           |__DNA_loop_anchor
           |__enhancer
           |   |__enhancer_bound_by_factor
           |   |__shadow_enhancer
           |__insulator 7692 rec.
           |   |__boundary_element
           |   |__enhancer_blocking_element
           |__locus_control_region
           |__silencer
               |__exonic_splicing_silencer
               |__intronic_splicing_silencer

Spanning Tree View Settings
Parents/Children View Depth	Show hierarchy levels: for parents, for children
Relationships
Is a	transcriptional_cis_regulatory_region
Part of
Synonyms & Secondary IDs
Synonyms
	"cis regulatory module" EXACT "CRM" EXACT "TF module" EXACT "transcription factor module" EXACT
Secondary IDs

External Crossreferences & Linkouts

Spanning Tree View Settings

Parents/Children
View Depth

Relationships

Is a

transcriptional_cis_regulatory_region

Part of

Synonyms & Secondary IDs

Synonyms

"cis regulatory module" EXACT
"CRM" EXACT
"TF module" EXACT
"transcription factor module" EXACT

Secondary IDs

External Crossreferences & Linkouts