FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dhc64CLab-1
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General Information
Symbol
Dmel\Dhc64CLab-1
Species
D. melanogaster
Name
FlyBase ID
FBal0004772
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
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Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Contrary to what occurs in wild-type, rudimentary centrosome like structures assemble in the entire cytoplasm of every unfertilised Dhc64CLab-1 egg. The centrosomes appear to nucleate small microtubule asters and contain what may be rudimentary centrioles. There is no indication of chromosome replication at this stage. Unlike wild-type, the centrosomes in fertilised, Dhc64CLab-1 eggs begin to replicate prior to accomplishment of mitosis, as shown by the presence of multiple centrosomes at the spindle poles. The centrosomes also detach from their nuclei following the first or second cleavage division in every fertilised mutant egg, and while the cleavage nuclei stop dividing and degenerate, the centrosome cycles proceed even in the absence of nuclei. The number of centrosomes increase exponentially with time and about 2 hours post fertilisation, the entire egg cortex is populated with free centrosomes that nucleate normal-looking microtubule asters. Both rudimentary centrosomes, which are characteristic of unfertilised mutant eggs, and normal centrosomes appear only in about 1% of the fertilised mutant eggs.

Female viability and male fertility are not reduced. The sperm pronuclei divide a few times in the eggs while the oocyte pronuclei remain still.

dominant female-sterile. In embryos from heterozygous females 1-3 large nuclei (probably sperm pronuclei).

External Data
Interactions
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Phenotypic Class
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Xenogenetic Interactions
Statement
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Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (6)
Reported As
Symbol Synonym
Dhc64CLab-1
Fs(3)Lab1
Fs(3)Laborc17c
Name Synonyms
Secondary FlyBase IDs
    References (5)