FlyBase Allele Report: Dmel\nompC[4]

General Information

Symbol

Dmel\nompC⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0008345

Feature type

allele

Associated gene

Dmel\nompC

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

Progenitor genotype

Cytology

Description

Amino acid replacement: C1400Y. Nucleotide substitution: G4820A.

(Walker et al., 2000)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

2L:5,360,139..5,360,139 [+]

Nucleotide change:

G5360139A

Amino acid change:

Reported amino acid change:

C1400Y

(Walker et al., 2000)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior

(Walker et al., 2000)

abnormal locomotor behavior | larval stage

(Cheng et al., 2010)

abnormal neurophysiology

(Walker et al., 2000)

uncoordinated

(Walker et al., 2000)

Phenotype Manifest In

Detailed Description

Statement

Reference

Crawling speed of homozygous larvae is reduced compared to controls.

(Cheng et al., 2010)

Mutants have greatly reduced but not eliminated sound-evoked antennal potentials.

(Lee et al., 2010)

nompC³/nompC⁴ mutants retain a preference for 18[o]C (i.e. are thermotactic).

(Kwon et al., 2008)

Flies show moderate uncoordination. Mechanoreceptor currents are comparable in amplitude to normal though adaptation is altered. Time constant for adaptation is reduced from wild type 277ms to 50ms. The frequency of action potentials is reduced two fold.

(Walker et al., 2000)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

nompC⁴ is rescued by nompC^+tC

(Walker et al., 2000)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Due to a naming clash that goes back many years, two different alleles of nompC, with contrasting molecular lesions, were named nompC[4]. Thanks to user input, we have been able to disambiguate these two alleles. They are now called nompC[4] and nompC[b19]. The nompC[4] allele was generated in the Zuker lab by EMS (FBrf0127378). The nompC[h25] allele was made by Szidonya and Reuter (FBrf0047784) and published in 1988 as jf24[h25]. Allele jf24[h25] was renamed in Lindsley and Zimm 1992 (p. 353) as l(2)25Dc[4]. Allele l(2)25Dc[4] subsequently became nompC[4] based on a foot note in Kernan et al., 1994 (FBrf0073546) identifying l(2)25Dc as nompC. The references and data for jf24[h25]/l(2)25Dc[4]/nompC[4] have now been split from the nompC[4] FlyBase record and are associated with allele nompC[h25].

(FlyBase, 2009-)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

l(2)25Dc⁴

l(2)jf24^h25

nompC⁴

(Li and Montell, 2021, Ma and Freeman, 2020, Cheng et al., 2010, Lee et al., 2010, Kwon et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (9)

Report Sections

Open Close