FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-41D12
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General Information
Symbol
Dmel\mei-41D12
Species
D. melanogaster
Name
FlyBase ID
FBal0012163
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
Carried in Construct
Also Known As
mus(1)103D1
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: H1869Y.

    (Laurencon et al., 2003)

    In addition to the H1869Y amino acid replacement, which may cause the mutant phenotype, a number of additional amino acid changes are present compared to the U34925 mei-41 GenBank sequence (these "common" mutations are also present in other mei-41 mutant alleles, possibly due to variability present in the mutagenised population).

    (Laurencon et al., 2003)

    Nucleotide substitution: C8053T.

    (Laurencon et al., 2003)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    X:16,398,044..16,398,044 [+]
    Nucleotide change:

    C16398044T

    Reported nucleotide change:

    C8053T

    Amino acid change:

    H2032Y | mei-41-PA

    Reported amino acid change:

    H1869Y

    Comment:

    The mutation site reported in FBrf0160718 is relative to GB:U34925 (in which the predicted CDS is missing 163 N-terminal amino acids relative to genome release 3.2). Other amino acid changes common to several mei-41 mutants are also present in the strain (see FBrf0160718).

    (Laurencon et al., 2003)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Irradiated homozygous embryos derived from homozygous embryos do not show a reduction in the number of mitotic cells in the dorsal ectoderm 20 minutes after irradiation, in contrast to wild-type embryos, which show a reduction in the number of mitotic cells after irradiation. Wild-type embryos show an increase in the ratio of metaphase to (anaphase+telophase) 40 minutes after irradiation, compared to unirradiated controls. This increase is severely diminished in homozygous embryos derived from homozygous females. 97% of eggs derived from homozygous females hatch into larvae. Hemizygous larvae show 63% loss of the G2/M checkpoint (this number is the average number of mitotic cells per eye disc after exposure of male hemizygous larvae to 500R of X rays expressed as a percentage of the number of mitotic cells per eye disc before irradiation, wild-type values range from 5 to 15%).

        (Laurencon et al., 2003)

        Homozygotes and hemizygotes do not show an increased frequency of spontaneous chromosome aberrations in neuroblast metaphases compared to wild-type larvae.

        (Gatti, 1979)

        Does not reduce meiotic exchange.

        External Data
        Interactions
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        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        mei-41D12 maps to 12A1-12A7 by deficiency mapping.

        (Mason et al., 1981)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (5)
        Reported As
        Symbol Synonym
        103D1
        (Gatti, 1979)
        mei-41103D1
        (Yamamoto et al., 1990)
        mei-41D12
        mus(1)103D1
        (Olsen and Green, 1982, Mason et al., 1981)
        mus103D1
        (Gamo et al., 1990)
        Name Synonyms
        Secondary FlyBase IDs
          References (8)