FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-41D15
Open Close
General Information
Symbol
Dmel\mei-41D15
Species
D. melanogaster
Name
FlyBase ID
FBal0012166
Feature type
allele
Associated gene
Dmel\mei-41
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Mason et al., 1981)
Progenitor genotype
Cytology
Description

Amino acid replacement: T652P.

(Laurencon et al., 2003)

In addition to the T652P amino acid replacement, which may cause the mutant phenotype, a number of additional amino acid changes are present compared to the U34925 mei-41 GenBank sequence (these "common" mutations are also present in other mei-41 mutant alleles, possibly due to variability present in the mutagenised population).

(Laurencon et al., 2003)

Nucleotide substitution: A4328C.

(Laurencon et al., 2003)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,394,319..16,394,319 [+]
Nucleotide change:

A16394319C

Reported nucleotide change:

A4328C

Amino acid change:

T815P | mei-41-PA

Reported amino acid change:

T652P

Comment:

The mutation site reported in FBrf0160718 is relative to GB:U34925 (in which the predicted CDS is missing 163 N-terminal amino acids relative to genome release 3.2). Other amino acid changes common to several mei-41 mutants are also present in the strain (see FBrf0160718).

(Laurencon et al., 2003)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      84% of eggs derived from homozygous females hatch into larvae. Hemizygous larvae show a G2/M checkpoint that is robust as in wild-type.

      (Laurencon et al., 2003)

      Hemizygous male larvae are not sensitive to HN2. They are sensitive to 0.08% MMS but relatively insensitive to 0.04% MMS.

      (Mason et al., 1981)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      mei-41D15
      mus(1)104D2
      (Mason et al., 1981)
      mus104D2
      Name Synonyms
      Secondary FlyBase IDs
        References (3)