FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\tur1
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General Information
Symbol
Dmel\tur1
Species
D. melanogaster
Name
FlyBase ID
FBal0017281
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
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Cytology
Description
Mutations Mapped to the Genome
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Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
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Marker for
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Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

When the original shock-odor testing system is modified by redesigning the choice chamber, homozygous and hemizygous mutants show about 60% of the control wild-type values when tested just post-training, but the mutant shows very rapid short-term and slower long-term memory losses.

Homozygous tur1 flies are said to have a deficiency in (and possibly absence of) protein kinase C (PKC), but the lowered PKC levels and abnormal learning do not map to the same cytogenetic location.

Homozygotes or hemizygotes are blocked or impaired in learning, with respect to certain of the conditioning tests used on groups of flies or larvae or on individual adults, e.g. tests involving 'courtship conditioning'.

Flies show abnormally low habituation to sucrose stimuli applied to the tarsus. Homozygotes or hemizygotes are blocked or impaired in learning, with respect to certain of the conditioning tests used on groups of flies or larvae or on individual adults, e.g. tests involving habituation to sugar stimuli when applied to tarsus.

Homozygotes or hemizygotes are blocked or impaired in learning, with respect to certain of the conditioning tests used on groups of flies or larvae or on individual adults, e.g. tests involving leg-shock/leg-lift learning.

Homozygotes or hemizygotes are blocked or impaired in learning, with respect to certain of the conditioning tests used on groups of flies or larvae or on individual adults, e.g. tests involving olfactory 'shock-avoidance' learning.

Homozygotes or hemizygotes are blocked or impaired in learning, with respect to certain of the conditioning tests used on groups of flies or larvae or on individual adults, e.g. tests involving olfactory 'shock-avoidance' learning. tur1/+ heterozygous females show seemingly normal levels of shock-odor conditioned behavior when tested immediately after training, but very rapid memory losses.

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Comments

Flies have dramatically reduced protein kinase C activity. Flies are deficient in phosphorylation of a 76kD head membrane protein, this defect correlates with tur+ gene dosage.

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Synonyms and Secondary IDs (3)
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    References (10)