FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmer\uraa
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General Information
Symbol
Dmer\uraa
Species
D. mercatorum mercatorum
Name
abnormal abdomen
FlyBase ID
FBal0033613
Feature type
allele
Associated gene
Dmer\ur
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
natural population
(Templeton et al., 1993)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies of the 'abnormal abdomen' strain have a higher level of Dmer\bb units with Dmer\R1-element and Dmer\R2-element insertions than wild-type flies. Uninserted Dmer\bb units do not undergo general underreplication in contrast to wild-type, although differential underreplication of the inserted Dmer\bb units does occur in the 'abnormal abdomen' strain.

      (Malik and Eickbush, 1999)

      Mutants have delayed production of juvenile hormone esterase and juvenilized abdominal cuticle. Egg to adult developmental time is slowed down by 0.92 days in females bearing the Dmer\uraa allele in nature, with no detectable slowdown in males. Females bearing the Dmer\uraa allele have a strong fecundity advantage in nature under some ecological conditions but not others.

      (Templeton et al., 1993)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Phenotype is only manifest when more than a third of the 18S/28S rDNA repeats are transcriptionally inactivated by the insertion of R1 repeats.

      (Templeton et al., 1993)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Dmer\uraa
      aa
      (Flatt et al., 2005, Malik and Eickbush, 1999)
      Name Synonyms
      abnormal abdomen
      (Flatt et al., 2005)
      underreplication<up>abnormal abdomen</up>
      (Flatt et al., 2005)
      Secondary FlyBase IDs
        References (6)