FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NintraΔ.hs.2sev.F
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General Information
Symbol
Dmel\NintraΔ.hs.2sev.F
Species
D. melanogaster
Name
FlyBase ID
FBal0104074
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Mutagen
Nature of the Allele
Carried in construct
Cytology
Description

The Scer\FRT cassette has been excised, juxtaposing the sev enhancer and N intracellular domain sequences.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ommatidia have a variable number of photoreceptors in flies carrying NintraΔ.hs.2sev.F, often four large rhabdomere cells and two or three small rhabdomere cells.

Ommatidia in which all cells carry NintraΔ.hs.2sev show severely disrupted patterns of photoreceptor differentiation. Ommatidia which are mosaic for NintraΔ.hs.2sev in an otherwise wild-type background can form the normal complement of 8 photoreceptors, provided that both the R1 and R6 cells do not carry NintraΔ.hs.2sev. When these normally composed ommatidia are mosaic for the R3/R4 pair, the cell carrying NintraΔ.hs.2sev invariably develops as the R4 photoreceptor, resulting in incorrect chirality in some cases (this phenotype is unaffected if the flies are also carrying fz15 or fz37). Ommatidia in which both members of the R3/R4 pair carry NintraΔ.hs.2sev can be symmetrical, although asymmetric ommatidia of the correct chiral form are also seen. The R8 cell body normally achieves an asymmetric position on the R3 rather than the R4 side of the ommatidium in wild-type flies. Frequent uncoupling of the R8 position from the R3/R4 asymmetry is seen in NintraΔ.hs.2sev mosaics. In these cases, R8 cells are usually found between R5/R6, occasionally found between R1/R6 and in rare cases are found between other cells.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
NintraΔ.hs.2sev.F
Name Synonyms
Secondary FlyBase IDs
    References (3)