FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\LamG262
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General Information
Symbol
Dmel\LamG262
Species
D. melanogaster
Name
FlyBase ID
FBal0147816
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Insertion maps to AE003610, sense orientation with respect to scaffold, insertion point 104227.

Allele components
Component
Use(s)
Mutations Mapped to the Genome
Curation Data
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

LamG262 escapers are slower to right themselves than controls. Heterozygous adults are indistinguishable from controls.

LamG262 homozygote escapers performed negative gravitaxis (climbing upwards) significantly less well than LamG262 heterozygotes. Homozygotes do not show any decrease beyond their initial low levels of negative gravitaxis over their 2 week survival period. The fraction of homozygous mutants that perform negative gravitaxis decreases over time and is always lower than age-matched controls. The decrease is much more dramatic for mutant flies, approaching zero at two weeks of age.

LamG262 homozygous and heterozygous mutants exhibit lower pupariation height, indicative of reduced larval locomotion and negative gravitaxis.

LamG262 mutant adult escapers do not exhibit great changes in muscle bulk, placement, or organisation. Muscle 5 in the larval abdominal body wall is often absent or slightly reduced in size and mis-inserted. In addition, fine structure defects in fibrillar organisation are also found in LamG262 larvae that are never observed in age-matched control larvae.

External Data
Interactions
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Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Based on lethality, the following alleles can form an allelic class, from the most severe to the weakest: LamP; LamD395; Lam04643; LamG262.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)