Insertion maps to AE003610, sense orientation with respect to scaffold, insertion point 104227.
LamG262 escapers are slower to right themselves than controls. Heterozygous adults are indistinguishable from controls.
LamG262 homozygote escapers performed negative gravitaxis (climbing upwards) significantly less well than LamG262 heterozygotes. Homozygotes do not show any decrease beyond their initial low levels of negative gravitaxis over their 2 week survival period. The fraction of homozygous mutants that perform negative gravitaxis decreases over time and is always lower than age-matched controls. The decrease is much more dramatic for mutant flies, approaching zero at two weeks of age.
LamG262 homozygous and heterozygous mutants exhibit lower pupariation height, indicative of reduced larval locomotion and negative gravitaxis.
LamG262 mutant adult escapers do not exhibit great changes in muscle bulk, placement, or organisation. Muscle 5 in the larval abdominal body wall is often absent or slightly reduced in size and mis-inserted. In addition, fine structure defects in fibrillar organisation are also found in LamG262 larvae that are never observed in age-matched control larvae.
Based on lethality, the following alleles can form an allelic class, from the most severe to the weakest: LamP; LamD395; Lam04643; LamG262.