FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\sinunwu7
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General Information
Symbol
Dmel\sinunwu7
Species
D. melanogaster
Name
FlyBase ID
FBal0154586
Feature type
allele
Associated gene
Dmel\sinu
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Wu et al., 2004)
Mutagen
P-element activity
(Wu et al., 2004)
Progenitor genotype
P{PZ}sinu06524
(Wu et al., 2004)
sinu06524
(Wu et al., 2004)
Caused by aberration
Df(3L)sinunwu7
Cytology
Description

Imprecise excision of the P{PZ}sinu06524 element, resulting in a deletion of all the amino acids of the sinu open reading frame, without affecting the coding sequences of adjacent genes.

(Wu et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant embryos have elongated trachea.

      (Nelson et al., 2010)

      Stage 17 homozygous embryos show loss of the blood brain barrier (assayed by studying dextran uptake in living embryos).

      (Stork et al., 2008)

      The transepithelial diffusion barrier is compromised in homozygous embryos; a 10kD dye injected into the body cavity crosses the salivary gland epithelium in mutant embryos (in contrast to wild-type embryos). Numerous, well-differentiated septa are present in the cells of trachea, epidermis and salivary glands in late stage 17 mutant embryos. However, the total number of septa is significantly reduced, there a fewer groups of septa and the septa are not organised into continuous circumferential ribbons. Septa remain localised to the apical half of the lateral plasma membrane and the zonula adherens appears normal. Tracheal cells show additional defects in addition to the disruption of the septate junctions; the taenidium shows a highly irregular folding pattern in mutant embryos, in contrast to the regular pattern seen in wild-type embryos. The mutant tracheal cells have an unusually large number of vesicles in the cytoplasm.

      (Wu et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The tracheal length defects of kuneC309 pckG0012 sinunwu7 triple mutant embryos are no more severe than those of single mutants.

      (Nelson et al., 2010)

      Trachea in Nrx-IV4865 sinunwu7 double mutants have the same phenotypes as either single mutant. The tracheal defects of sinunwu7 mutant embryos are more severe in double mutant combination with nrv223B (expansion of the tube diameter is more severe in the transverse connective and visceral branches), vari03953b or convk06507b (severe diameter defects are seen in all multicellular branches and dorsal trunk length appears increased in both cases). sinunwu7 nrv2nwu3 double mutants have cyst-like structures in the tracheal ganglionic branches. The trachea of sinunwu7 scribj7B3 double mutants have the same phenotype as sinunwu7 single mutants.

      (Wu et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      sinunwu7 is partially rescued by Scer\GAL4btl.PS/sinuUAS.cWa

      (Wu et al., 2004)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      sinuNWU7
      (Stork et al., 2008)
      sinunwu7
      (Khadilkar et al., 2017, Tempesta et al., 2017, Hall et al., 2014, Nelson et al., 2010, Wu et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)