FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\frtz33
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General Information
Symbol
Dmel\frtz33
Species
D. melanogaster
Name
FlyBase ID
FBal0179810
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

1bp insertion in exon 3 (GATCTGCT > GATCCTGCT). The mutant protein contains the N-terminal 309 residues plus 37 novel amino acids.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Strong allele. The bristles (macrochaetae and microchaetae) of the adult notum and abdomen of frtz33 hemizygotes have an altered orientation and usually point towards the midline (in wild-type flies these bristles point posteriorly). Cell hair polarity and number are altered in the wing, with the cell hair polarity phenotype being stronger at 18oC than 29oC. At 18oC, substantial regions of reversed (proximal pointing) hair polarity are seen, especially on the ventral wing surface. Most cells showing reversed wing hair polarity have wild-type hair number, although a high proportion of cells produce two or more cell hairs in the mutant wing. Small homozygous clones in the wing can display hair polarity phenotypes, but no substantive changes in polarity are seen outside of the clone. Cells at the edges within a homozygous clone often produce additional wing hairs, whereas cells surrounding the clone never do. This indicates that the wing hair phenotype is cell autonomous. The change of cell hair polarity seen in the clones is similar to that at the same position of a homozygous wing. Homozygous first instar larvae show abnormal patterning of ventral denticles; both the spacing and the alignment of denticles within the denticle rows is disrupted, especially in the three anterior rows of the denticle belts. The mutant denticles still point anteriorly or posteriorly, as in wild type. Individual denticles often appear smaller than normal.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (2)