FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Npc1aRNAi.cHa
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General Information
Symbol
Dmel\Npc1aRNAi.cHa
Species
D. melanogaster
Name
FlyBase ID
FBal0189836
Feature type
allele
Associated gene
Dmel\Npc1a
Associated Insertion(s)
Carried in Construct
P{UAS-Npc1a.RNAi.H}
Key Links
Transgenic product class
RNAi_reagent
(Huang et al., 2005)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Huang et al., 2005)
Mutagen
in vitro construct
(Huang et al., 2005)
Progenitor genotype
Carried in construct
P{UAS-Npc1a.RNAi.H}
Cytology
Description

Template corresponding to nucleotides 3086-3606 of Npc1a cDNA.

(Huang et al., 2005)
Allele components
Component
Use(s)
Encoded product / tool
Npc1a
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Embryos injected with NPC1dsRNA.cHa develop normally during embryogenesis but 65% of these animals dies during the first larval stage.

      (Huang et al., 2005)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      dsRNA has been synthesised from the template and injected into embryos to study the phenotypic consequences of dsRNA interference (RNAi) of the NPC1 gene.

      (Huang et al., 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NPC1dsRNA.cHa
      Npc1aRNAi.cHa
      Npc1adsRNA.cHa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)