FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\twinGS12209
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General Information
Symbol
Dmel\twinGS12209
Species
D. melanogaster
Name
FlyBase ID
FBal0197363
Feature type
allele
Associated gene
Dmel\twin
Associated Insertion(s)
P{GSV6}twinGS12209
Carried in Construct
Also Known As
twin12209
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GSV6}twinGS12209
    Cytology
    Description

    The P{GSV6}twinGS12209 insertion maps within a region that overlaps both the twin and cav genes (the insertion is in the twin 5'UTR, in the same orientation as the direction of transcription of twin). The chromosome complements a null allele of cav for both lethality and ovarian phenotypes, indicating that the mutant phenotype is due to an effect on twin and not cav.

    (Zaessinger et al., 2006)
    Allele components
    Component
    Use(s)
    Inserted element
    P{GSV6}
    Regulatory region(s)
    UASt
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        twinGS8115/twinGS12209 larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

        (Pradhan et al., 2012)

        Embryos derived from twinGS12209/Df(3R)Exel6198 females mated to wild-type males show 66% lethality.

        15% of embryos derived from twinGS12209/Df(3R)crb-F89-4 females that develop a cuticle have head defects, including complete loss of head structures.

        Embryos derived from a cross of homozygous males and females show 94% lethality.

        Embryos derived from twinGS12209/twinGS12209 females mated to wild-type males show 53% lethality.

        Homozygous females show a number of ovarian defects; 60.5% of egg chambers are wild-type, but 4% have less than 15 nurse cells, 17.5% have more than 15 nurse cells, 14% show degeneration and 4% have other defects.

        twinGS12209/Df(3R)crb-F89-4 females show a number of ovarian defects; 37% of egg chambers are wild-type, but 7.5% have less than 15 nurse cells, 32% have more than 15 nurse cells, 17.5% show degeneration and 6% have other defects. Eggs chambers containing oocytes with five ring canals are seen, indicating that the cyst has undergone an extra round of division.

        (Zaessinger et al., 2006)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        twinGS12209/+ ; Patr-1d3/+ double heterozygous larvae show a significant increase in the number of type 1b boutons at the muscle 6/7 neuromuscular junction compared to controls.

        (Pradhan et al., 2012)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        twin12209
        (Barckmann et al., 2015, Zaessinger et al., 2006)
        twinGS12209
        (Pradhan et al., 2012)
        Name Synonyms
        Secondary FlyBase IDs
          References (3)