FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\ms(3)Z2203Z2203
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General Information
Symbol
Dmel\ms(3)Z2203Z2203
Species
D. melanogaster
Name
FlyBase ID
FBal0216856
Feature type
allele
Associated gene
ms(3)Z2203
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Ceprani et al., 2008)
Mutagen
ethyl methanesulfonate
(Ceprani et al., 2008)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutant spermatocytes show a defect in both the ks-1 and kl-5 Y-loops, but not in the kl-3 Y-loop. The ks-1 loop is frequently either absent or strongly reduced and fragmented. Spermatids are defective, with large Nebenkern associated with macro- and micro-nuclei (suggesting a failure in both chromosome segregation and cytokinesis).

      Defects are seen in male meiosis; chromatin fails to compact in prometaphase nuclei of primary spermatocytes and the chromatin is still undercondensed at later stages, although it eventually reaches a level of compaction similar to wild type. In addition, the spindle fibres lose their organisation.

      ms(3)Z2203Z2203/Df(3R)by10 hemizygous males show the same phenotype as ms(3)Z2203Z2203 homozygotes.

      (Ceprani et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      162-039
      (Piergentili, 2008.5.28)
      ms(3)162-39
      (Ceprani et al., 2008)
      ms(3)Z2203Z2203
      Name Synonyms
      Secondary FlyBase IDs
        References (2)