FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Mco3C359
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General Information
Symbol
Dmel\Mco3C359
Species
D. melanogaster
Name
FlyBase ID
FBal0216996
Feature type
allele
Associated gene
Dmel\Mco3
Associated Insertion(s)
PBac{3HPy+}Mco3C359
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{3HPy+}Mco3C359
    Cytology
    Description

    PBac{3HPy+}MCO3C359 disrupts the open reading frame of MCO3 at amino acid 550, roughly in the middle of the protein sequence, generating a predicted null mutation.

    (Bettedi et al., 2011)
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        MCO3C359 homozygous and MCO3C359/Df(3R)BSC140 trans-heterozygous larvae exhibit an increase in iron storage in the middle midgut, both in the presence and absence of dietary copper. However, MCO3C359 mutants do not differ in their total iron content but exhibit higher copper and lower manganese accumulation compared with controls when compared to control flies. Zinc levels are not affected. Feeding these mutants a high copper diet leads to significantly lower copper accumulation than in controls, suggesting copper homeostasis may be affected.

        (Bettedi et al., 2011)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        MCO3C359;Mvl97f double mutants exhibit an increase in iron storage compared to Mvl97f single mutants, indicating MCO3 can suppress the iron depletion phenotype seen in Mvl mutants.

        MCO3C359;Mvl97f double mutant flies do not show statistically significant differences in iron content when compared to controls or Mvl97f single mutants (which are low in iron). MCO3C359;Mvl97f double mutant exhibit normal copper content, suggesting that Mvl97f suppresses the MCO3C359-related copper accumulation phenotype.

        MCO3C359;Mvl97f double mutants exhibit low manganese content, similar to MCO3C359 single mutants.

        (Bettedi et al., 2011)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (3)
        Reported As
        Symbol Synonym
        CG5959C359
        (Bettedi et al., 2011)
        MCO3C359
        Mco3C359
        Name Synonyms
        Secondary FlyBase IDs
          References (2)