HisCl1^T1/Df(3R)E79 flies take a similar time to become paralysed at 41[o]C as control flies. The mutant flies take longer to recover when returned to 20[o]C than control flies.

HisCl1^T1/Df(3R)E79 flies show no significant difference in the time that exposure to halothane results in lethality compared to controls. The mutant flies show a normal rate of knock-down on exposure to halothane, but they show a significantly delayed recovery from anaesthesia after exposure to halothane.

The amplitudes of the on- and off-transients of the electroretinogram are higher in HisCl1^T1/Df(3R)E79 flies than in wild-type controls. The 0.5mV thresholds of both on- and off-transients of the mutant flies are lower than those of the wild-type controls, indicating a higher absolute sensitivity of both transients in the mutants. The sensitivity of the on- and off-responses is increased to a similar degree.

HisCl1^T1/Df(3R)E79 adults show a slightly reduced survival after exposure to DMSO compared to control flies.

HisCl1^T1/Df(3R)E79 adults show significantly reduced survival compared to controls after treatment with 0.5μM ivermectin.

The electroretinograms of HisCl1^T1/Df(3R)E79 flies have the same general shape as those of control flies, and the mean amplitude of the photoreceptor component is similar to that of controls over the entire range of light intensities. However, the amplitude of the on-transient is greater in the mutant flies than in controls over a range of light intensities, while the amplitude of the off-transient is larger than normal in the mutant flies at log Is (-3) and (-2).

HisCl1^T1/Df(3R)E79 flies show a hypersensitivity to ivermectin compared to control flies when assayed using electroretinogram recordings; the mutants show almost complete elimination of transients at 0.5μM ivermectin and complete loss of transients at 2.5 and 3.75μM. The decay of the photoreceptor potential component of the electroretinogram in the presence of ivermectin is systematically steeper in the mutants than in controls.