FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\InR574
Open Close
General Information
Symbol
Dmel\InR574
Species
D. melanogaster
Name
FlyBase ID
FBal0268680
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Nature of the Allele
Allele class
Progenitor genotype
Cytology
Description

Amino acid replacement: W1562term.

Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Nucleotide change:

G21575141A

Amino acid change:

W1562term | InR-PA; W1562term | InR-PB; W1562term | InR-PC; W1562term | InR-PD

Reported amino acid change:

W1562term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

InR574/InR574 somatic clones of terminal tracheal cells are smaller in size, but have a similar nucleus size and branch number to heterozygous controls in third instar larvae. Heterozygous neighboring stalk cells show a mild capacity for compensatory branching leading to a slight increase in the occurrence of two or more adherens junctions between the two cells, compared to one junction in wild-type controls.

InR574/InR574 somatic clones of tracheocytes in the dorsal trunk are also smaller in size and tend to be oval in shape rather than hexagonal, as observed for control wild-type clones.

sprout574 mutant terminal cells are tiny, but the tracheal cells are nevertheless robustly branched.

sprout574 mutant eye cell clones,in an EGUF/hid eye assay (where forced expression of a cell death gene in the eye imaginal disc eliminates wild-type cells, leaving the adult eyes to develop almost entirely from clones of homozygous mutant cells), exhibit a growth defect.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (3)