FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\gsbs252
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General Information
Symbol
Dmel\gsbs252
Species
D. melanogaster
Name
FlyBase ID
FBal0295041
Feature type
allele
Associated gene
Dmel\gsb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(He and Noll, 2013)
Mutagen
ends-in gene targeting
(He and Noll, 2013)
Progenitor genotype
Cytology
Description

The following mutations have been introduced into exon 2 of gsb : a single base pair deletion (generating a frameshift and a SmaI site), an additional point mutation and two adjacent consecutive in-frame ochre and amber stop codons. The mutations truncate the gsb protein after Gly84, the 66th amino acid of the paired domain.

(He and Noll, 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The overall organisation of the central nervous system is severely disrupted in gsbs252 mutant embryos, but the medially projecting neurites and the somata of the SNa motor neurons are recognisable in most hemisegments.

      Mutant embryos show replacement of the posterior part of the segment with a mirror-image duplication of denticle belts normally found in the anterior part in only 13% of segments.

      (He and Noll, 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      gsbs252
      (He and Noll, 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)