FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\ncdY485K.TSmod
Open Close
General Information
Symbol
Dmel\ncdY485K.TSmod
Species
D. melanogaster
Name
FlyBase ID
FBal0413592
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

The ncd promoter drives expression of a fluorescence resonance energy transfer (FRET)-based sensor that is designed to measure tension along a gain-of-function ncd kinesin motor. The sensor consists of the full-length ncd coding sequence, with a Y485K mutation that reduces the strength of binding to ADP and increases the strength of binding to microtubules, resulting in a gain-of-function protein with increased motor velocity and mechanical output. A tension-sensing module (TSmod) has been inserted at K210 near the ncd tail-stalk junction. The tension-sensing module comprises two fluorescent proteins - mTFP1 (FRET donor) and Venus (FRET acceptor) - separated from each other by a stretchable domain from spider silk (PMID:20613844). Under low tension high FRET is produced, but under high tension, the two fluorophores move further apart, reducing the FRET signal.

Allele components
Component
Use(s)
Regulatory region(s)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
ncdY485K.TSmod
Name Synonyms
Secondary FlyBase IDs
    References (1)