Gene Group: R-SNAREs

General Information

Name

R-SNAREs

Species

D. melanogaster

Symbol

R-SNARE

FlyBase ID

FBgg0000042

Date last reviewed

2013-12-12

Number of members

Description

R-SNAREs are members of the SNARE (soluble N-ethylmaleimide-sensitive factor-attachment protein (SNAP) receptor) family that mediate vesicle-fusion. SNAREs are cytoplasmic, membrane-anchored proteins that contain a 60 amino acid SNARE domain. Three Q-SNAREs domains from the target membrane and one R-SNARE domain from the vesicle interact to form a four-helix bundle that pulls the two membranes in close proximity and promotes fusion. After fusion, the complexes are dissembled by NSF (N-ethylmaleimide-sensitive factor) and SNAPs (Soluble NSF Attachment Proteins). R-SNAREs are named from their contribution of a conserved arginine (R) residue to the helix bundle. (Adapted from PMID:15893389 and FBrf0216182).

Notes on Group

FBrf0216182 details the phylogentic sub-groups of the R-SNAREs.

l(2)gl and Tomosyn, which have been shown to interact with SNAREs have been omitted from the R-SNARE gene group. Tomosyn does not contain a transmembrane anchor at the end of its R-SNARE motif, therefore cannot serve as a fusogenic R-SNARE. It may modulate SNARE-mediate fusion. l(2)gl possesses a very similar N-terminal domain to Tomosyn, but it has lost the C-terminal R-SNARE motif (FBrf0227489).

Source Material

The R-SNAREs Gene Group has been compiled using the following publication(s): Kloepper et al., 2008, Rossi et al., 2004, and Littleton, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

SNAP receptor activity

Biological Process

vesicle-mediated transport

vesicle fusion

Cellular Component

SNARE complex

Related Gene Groups

Parent group(s)