Gene Group: GATOR COMPLEXES

General Information

Name

GATOR COMPLEXES

Species

D. melanogaster

Symbol

SEA

FlyBase ID

FBgg0000050

Date last reviewed

2016-07-07

Number of members

Description

The GATOR (or SEA, Seh1-associated) complex is an upstream regulator of the TOR Complex 1 (TORC1). It is composed of two putative subcomplexes, GATOR1 and GATOR2. GATOR1 possesses Rag GTPase activating protein activity and inhibits TORC1 activity in response to amino acid starvation. GATOR2 suppresses the activity of GATOR1. Many of the subunits share features with vesicle coat proteins and tethering complexes and it is proposed that the GATOR complex plays a role in trafficking and autophagy. (Adapted from FBrf0232362, FBrf0223060 and PMID:25934700).

Notes on Group

Source Material

The GATOR COMPLEXES Gene Group has been compiled using the following publication(s): Cai et al., 2016, Wei et al., 2016, Dokudovskaya et al., 2011, and Dokudovskaya et al., 2011 .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

Cellular Component

Seh1-associated complex

Related Gene Groups

Parent group(s)

INTRACELLULAR TRANSPORT COAT, SCAFFOLD AND ADAPTOR PROTEINS

Component group(s)

GATOR1 COMPLEX

GATOR2 COMPLEX

Members (8)