FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Pathway: KETOLYSIS
Open Close
General Information
Name
KETOLYSIS
Species
D. melanogaster
Symbol
KETOLYS
FlyBase ID
FBgg0002215
Date last reviewed
2026-05-18
Number of members
3
Description
Description
Ketolysis occurs in the mitochondrion where the ketone bodies acetoacetate and (R)-3-hydroxybutyrate ((R)-3-hydroxybutanoate) are oxidized to acetyl-CoA, which is then fed into the tricarboxylic acid (TCA) cycle for energy production. Tissues use ketone bodies as an energy source when nutrients are scarce. (Adapted from FBrf0261870.)
Notes

Acetoacetate and 3-hydroxybutanoate are thought to be imported into cells via transporters belonging to the monocarboxylate transporter (MCT) family. So far, only Sln has been shown to be involved in acetoacetate uptake by neurons. The mitochondrial transporters are not known. Acat2 is a paralog of Acat1. As it is predicted to localize in the cytosol and there is no information for its involvement in ketone body metabolism, Acat2 is not included in the list.

Source Material
The KETOLYSIS Gene Group has been compiled using the following publication(s): Krejčová et al., 2025 .
Key Gene Ontology (GO) terms
Biological Process
Cellular Component
Related Gene Groups
GO Causal Activity Model (GO-CAM)
Members (3)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
69c59f8a00001866
Synonyms and Secondary IDs
Synonym(s)
KETOLYS
KETOLYSIS
ketone body catabolism
ketone body oxidation
Secondary FlyBase ID(s)
References (2)