FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: maturity-onset diabetes of the young
Open Close
General Information
Name
maturity-onset diabetes of the young
FlyBase ID
FBhh0000481
Disease Ontology Term
Parent Disease
OMIM
MATURITY-ONSET DIABETES OF THE YOUNG; MODY
Overview

This report describes general characteristics of the group of diseases termed maturity-onset diabetes of the young (MODY). Maturity-onset diabetes of the young is defined as an autosomal dominant form of diabetes typically occurring before 25 years of age and caused by primary insulin secretion defects. Since there is increasing incidence of polygenic type 2 diabetes in childhood and adolescence, and patients with gene mutations characteristic of MODY often present with clinical diabetes later in life, substituting the term 'autosomal dominant type 2 diabetes' has been proposed. Up to 5% of all diabetes cases may be due to MODY. Noninsulin-dependent diabetes mellitus (see FBhh0000153) is distinct from MODY in that it is polygenic and characterized by variation due to gene-gene and gene-environment interactions.

Subtypes of MODY are listed in the table below, with a link to the human disease model report for the subtype studied in flies.

[updated Jul. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: maturity-onset diabetes of the young
OMIM report
Symptoms and phenotype

Up to 5% of all diabetes cases may be due to MODY. (http://www.health.harvard.edu/diabetes/maturity-onset-diabetes-of-the-young-mody)

(FlyBase Curators, 2013-)

Maturity-onset diabetes of the young is defined as an autosomal dominant form of diabetes typically occurring before 25 years of age and caused by primary insulin secretion defects. Since there is increasing incidence of polygenic type 2 diabetes in childhood and adolescence, and patients with gene mutations characteristic of MODY often present with clinical diabetes later in life, substituting the term 'autosomal dominant type 2 diabetes' has been proposed. [from MIM:606391; 2017.01.23]

(OMIM, 2013-)

Noninsulin-dependent diabetes mellitus is distinct from MODY in that it is polygenic, characterized by gene-gene and gene-environment interactions with onset in adulthood, usually at age 40 to 60 but occasionally in adolescence if a person is obese. [from MIM:125853; 2017.01.23]

(OMIM, 2013-)
Genetics

Eleven different types of MODY have been identified, caused by changes in 11 different genes. Treatment varies, depending on the type of MODY. (http://www.health.harvard.edu/diabetes/maturity-onset-diabetes-of-the-young-mody)

(FlyBase Curators, 2013-)
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
autosomal dominant type 2 diabetes
Mason-type diabetes
MODY
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (2)