FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: cardiomyopathy
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General Information
Name
cardiomyopathy
FlyBase ID
FBhh0000508
Disease Ontology Term
Parent Disease
OMIM
Overview

Cardiomyopathy is characterized by progressive deterioration of the heart muscle; a large number of human genes have been implicated in the development of cardiomyopathy. Multiple different forms of familial cardiomyopathy have been modeled in Drosophila, including dilated cardiomyopathy (FBhh0000134), familial hypertrophic cardiomyopathy (FBhh0000409), and familial restrictive cardiomyopathy (FBhh0000425). A number of human genes are implicated in more than one form of cardiomyopathy; for these cases, reports of experimental results in flies have been organized by causative gene (see Related Diseases section, below) and cross-referenced under specific disease categories.

Cardiomyopathy associated with a high-fat diet (FBhh0000483) or a high-sugar diet (FBhh0000482) has also been studied in Drosophila. For a number of neurodegenerative or syndromic diseases that are associated with cardiomyopathy, that aspect of the disease has been investigated in flies; see Parkinson disease 2 (FBhh0000008), Huntington disease (FBhh0000003), and Noonan syndrome (FBhh0000131).

[updated Feb. 2017 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: cardiomyopathy
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Cardiomyopathy refers to diseases of the heart muscle. The heart muscle becomes enlarged; it may become thick and more rigid or it may stretch and become thinner. As the condition worsens, the heart becomes weaker and less able to pump blood through the body and maintain a normal electrical rhythm. The result can be heart failure or irregular heartbeats (arrhythmias). The main types of cardiomyopathy are: (1) dilated cardiomyopathy, (2) hypertrophic cardiomyopathy, (3) restrictive cardiomyopathy and (4) arrhythmogenic right ventricular dysplasia. (http://www.heart.org/HEARTORG/Conditions/More/Cardiomyopathy/What-Is-Cardiomyopathy-in-Adults_UCM_444168_Article.jsp#.WLSbuiHysUE)

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
cardiovascular disease
heart disease
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Cardiovascular Diseases
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (23)