FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: obesity, susceptibility to (postulated), DNAH10-related
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General Information
Name
obesity, susceptibility to (postulated), DNAH10-related
FlyBase ID
FBhh0001024
Disease Ontology Term
Parent Disease
OMIM
Overview

The human gene DNAH10 was identified in a meta-analysis of protein-coding genetic variants that influence waist-to-hip ratio, after adjusting for body mass index, which is associated with increased risk of type 2 diabetes and coronary heart disease. The analysis included 476,546 individuals, 88% with European ancestry and 12% with South and East Asian, African, or Hispanic/Latino ancestry. The human DNAH10 gene has not been introduced into flies.

There is one high-scoring ortholog of DNAH10 in flies, Dhc98D, along with several low-scoring orthologs. Multiple RNAi targeting constructs and one P-element insertion lines have been generated for Dhc98D.

Dhc98D knockdown using neuronal and fat body GAL4 drivers causes a significant increase in the levels of triglycerides.

[updated May 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: obesity, susceptibility to (fly models overview)
Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)
Specific Disease Summary: obesity, susceptibility to (postulated), DNAH10-related
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information

DNAH10 encodes a dynein axonemal heavy chain protein found in cilia and flagella. Mutations in DNAH10 have been reported to co-segregate with abnormally high circulating HDL-cholesterol levels (pubmed:24891332). In Drosophila, Dhc98D is part of the inner dynein arm complex I1/f, and has a testis-specific knockdown phenotype, unlike other dynein heavy chains like Dhc93AB (DNAH11) which have a defective cilia phenotype in chordotonal neurons (Zur Lage et al. 2019, FBrf0241470).

(FlyBase Curators, 2013-)
External links
Disease synonyms
Ortholog Information
Human gene(s) in FlyBase
    Human gene (HGNC)
    Symbol / Name
    DNAH10; dynein axonemal heavy chain 10
    D. melanogaster ortholog (based on DIOPT)
    Dmel\Dhc98D
    (DIOPT, 2013-)
    Comments on ortholog(s)

    One human gene to one fly gene; Dhc98D is the only high-ranking ortholog. There are multiple low-ranking orthologs in both flies and humans.

    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (1)
      Dmel\Dhc98D
      Gene Snapshot
      Contributions welcome
      Molecular function (GO)
      Cellular component (GO)
      Gene Groups / Pathways
      Comments on ortholog(s)

      Single, high-ranking ortholog of human DNAH10.

      Orthologs and Alignments from DRSC
      DIOPT - DRSC Integrative Ortholog Prediction Tool - Click the link below to search for orthologs in Humans
      H. sapiens (Human)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (1 groups)
        Dhc98D
        protein-protein
        Interacting group
        Assay
        References
        Dhc98D - Nnf1a
        anti tag coimmunoprecipitation, peptide massfingerprinting
        (Przewloka et al., 2007)
        Alleles Reported to Model Human Disease (Disease Ontology) (1 alleles)
        Dhc98D
        Models Based on Experimental Evidence ( 1 )
        Allele
        Disease
        Evidence
        References
        Dhc98DRNAi.UAS.cUa
        model of  obesity
        CEA
        (Justice et al., 2019)
        Modifiers Based on Experimental Evidence ( 0 )
        Allele
        Disease
        Interaction
        References
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Related mammalian, viral, bacterial, or synthetic transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Dhc98DHMC06494
        P{TRiP.HMC06494}
        y1 sc* v1 sev21; P{TRiP.HMC06494}attP40
        Dhc98DRNAi.UAS.cUa
        P{UAS-Dhc98D.RNAi.U}
        Dhc98DGD9575
        P{GD9575}
        Dhc98DKK105507
        P{KK105507}
        P{KK105507}VIE-260B
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (3)