• depressive disorder

The human miRNA MIR184 was identified from a RNA-seq experiment comparing miRNA expression from participants with late-life depression and controls. MIR184 has also been linked to a rare eye disease, EDICT syndrome (MIM:614303).

There is an orthologous miRNA in Drosophila, mir-184 (see FBrf0215696). Amorphic alleles, fluorescently tagged constructs, overexpression constructs, and a "sponge" sequestering construct have been generated for mir-184.

The human gene MIR184 has not been introduced into flies.

Flies lacking mir-184 have higher locomotor activity compared to controls at 11-15 days post eclosion, but lower locomotor activity at 21-25 days post eclosion. mir-184 knockout flies also have worse short- and long-term memory of an aversive odor stimulus than controls. Conversely, flies overexpressing mir-184 show better locomotor activity and memory than controls. The biological pathways and processes predicted to be affected by mir-184 were mainly related to the regulation of the immune-inflammatory processes (MAP kinase, Calmodulin-kinases, NF-kappa B signaling pathway), second messenger signaling (TRP channels activation, regulation of activation of G protein in gated potassium channels calcium signaling pathway, GABA receptor activation), metabolic control (insulin signaling pathway), neurotrophic support (neurotrophic signaling pathway, VEGF signaling pathway), proteostasis and senescence-related pathways (mTOR signaling pathway).

[updated June 2019 by FlyBase; FBrf0222196]