FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: obesity model, prolonged larval stage
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General Information
Name
obesity model, prolonged larval stage
FlyBase ID
FBhh0001105
Disease Ontology Term
Parent Disease
OMIM
Overview

A fly model of obesity uses a genotype that blocks normal larval development by reducing ecdysone. Larvae develop at almost normal rate but fail to undergo pupariation; they continue to feed and exhibit an increase in body weight and in fat cell size. Characteristics of obesity are observed, including accumulation of triglycerides and insulin resistance.

This system has been used to model and investigate adipocyte tissue macrophage infiltration. Hemocytes (macrophage-like cells in insects) infiltrate the fat body of obese larvae, mimicking the chronic inflammation present in human obesity.

[updated Jul. 2019 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: obesity, susceptibility to (fly models overview)
Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)
Specific Disease Summary: obesity model, prolonged larval stage
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology

Obesity is characterized by a chronic state of low-grade inflammation with progressive immune cell infiltration into adipose tissues (reviewed in Bai and Sun, 2015; pubmed:25586506).

(FlyBase Curators, 2013-)
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (2)