FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: high-sugar diet, nephropathy
Open Close
General Information
Name
high-sugar diet, nephropathy
FlyBase ID
FBhh0001117
Disease Ontology Term
Parent Disease
OMIM
Overview

Adult flies fed a high-sugar diet (post-eclosion) exhibit progressive nephrocyte dysfunction, including severely compromised nephrocyte diaphragms (comparable to mammalian slit diaphragms); this is consistent with phenotypes observed upon loss of the fly nephrin-like protein Dmel\sns (see FBhh0000318). Additional characterizations of genes and pathways affected in this system have suggested therapeutic options. Effects of chronic exposure of high sugar diet on renal tubules have been investigated using the Malpighian tubules of flies.

See the human disease model report 'kidney disease (fly models overview)' (FBhh0000738) for information on the fly renal system.

[updated Mar. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: high-sugar diet, nephropathy
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Diabetic nephropathy (DN) is one of the commonest microvascular complications of diabetes and has been the major cause of end-stage renal disease in many countries (Feng et al., 2019, pubmed:31632538; Bose et al., 2017, pubmed:28935636).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    diabetic nephropathy
    high-sugar diet, renal tubular dysfunction
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (16)