FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: chronic inflammatory lung disease
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General Information
Name
chronic inflammatory lung disease
FlyBase ID
FBhh0001341
Disease Ontology Term
Parent Disease
OMIM
Overview

Chronic inflammatory lung diseases, which include asthma and chronic obstructive pulmonary disease (COPD), have been modeled in Drosophila. Chronic airway inflammation is thought to be the primary underlying cause of these diseases. Extensive remodeling of the airways is a major characteristic of chronic inflammatory lung diseases.

In fly models, chronic airway inflammation is induced using several different methods: exposure to cigarette smoke, airway exposure to a bacterial trigger, and molecular induction via expression of the Imd signaling pathway (FBgg0001194) in tracheal cells. Airway remodeling has been observed and molecularly characterized in the fly models.

See, also, the human disease model report 'asthma, susceptibility to, ORMDL3-related' (FBhh0001038).

[updated Apr. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: chronic inflammatory lung disease
OMIM report
Human gene(s) implicated
Symptoms and phenotype

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases including chronic obstructive pulmonary disease (COPD), asthma, and pulmonary fibrosis. Chronic inflammation in the lung may arise from a combination of genetic susceptibility and environmental influences, including exposure to microbes, particles from the atmosphere, irritants, pollutants, allergens, and toxic molecules (Racanelli et al., 2018; pubmed:29130366).

(FlyBase Curators, 2013-)
Genetics
Cellular phenotype and pathology

Airway remodeling is broadly defined as any change in composition, distribution, thickness, mass or volume and/or number of structural components observed in the airway wall of patients relative to healthy individuals. Chronic airway inflammation is the major force driving the processes leading to most aspects of airway remodeling (Fehrenbach, et al., 2017; pubmed:28190087).

(FlyBase Curators, 2013-)

Extensive remodeling of the airways is a major characteristic of chronic inflammatory lung diseases such as asthma or chronic obstructive pulmonary disease.

(FlyBase Curators, 2013-)
Molecular information
External links
    Disease synonyms
    Search term: asthma
    Search term: chronic obstructive pulmonary disease
    Search term: COPD
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
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          Publicly Available Stocks
          References (21)