FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Human Disease Model Report: cognitive impairment, drug-induced
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General Information
Name
cognitive impairment, drug-induced
FlyBase ID
FBhh0001551
Disease Ontology Term
    Parent Disease
    OMIM
    Overview

    Drug-induced cognitive impairment is a common condition caused by many different prescribed medications, and is characterized by deficits involving multiple cognitive domains including memory. Drosophila models have been used to investigate chemotherapy-induced cognitive impairment (CRCI), characterizing the neurotoxicity of the chemotherapeutic drugs cisplatin, cyclophosphamide, and doxorubicin.

    Five day old adults were fed chemotherapy drugs at three concentrations for three days, then assessed at 10, 20, or 30 days with neurological and neurocognitive testing (climbing assay, taste memory assay). Flies treated with chemotherapy drugs showed impaired climbing ability at 10 days. Flies treated with cisplatin or doxorubicin demonstrated impaired neurocognitive function as assessed by the taste memory assay.

    Tissue analysis was performed on cisplatin treated adult flies. Treated flies displayed increased levels of caspase activation, vacuolar neurodegeneration, elevated DNA damage, and elevated oxidative stress. Effects were more marked at higher cisplatin dosages (FBrf0257941).

    See the FlyBase chemical reports for cisplatin (FBch0000748), cyclophosphamide (FBch0000076), doxorubicin (FBch0000426).

    [updated Apr. 2024 by FlyBase; FBrf0222196]

    Disease Summary Information
    Disease Summary: cognitive impairment, drug-induced
    OMIM report
    Human gene(s) implicated
    Symptoms and phenotype

    Cognitive impairment subsequent to cancer chemotherapy has been well-documented. Observed difficulties include impairment in the domains of memory, attention, executive function, processing speed, visual and verbal memory, and language (Pendergrass, et al., 2018; pmid:29497579).

    (FlyBase Curators, 2013-)
    Genetics
    Cellular phenotype and pathology
    Molecular information
    External links
      Disease synonyms
      "chemobrain"
      CRCI
      Ortholog Information
      Human gene(s) in FlyBase
        Other mammalian ortholog(s) used
          D. melanogaster Gene Information (0)
          Other Genes Used: Viral, Bacterial, Synthetic (0)
            Summary of Physical Interactions (0 groups)
            Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
            Alleles Representing Disease-Implicated Variants
            Genetic Tools, Stocks and Reagents
            Sources of Stocks
            Contact lab of origin for a reagent not available from a public stock center.
            Bloomington Stock Center Disease Page
            Related mammalian, viral, bacterial, or synthetic transgenes
            Allele
            Transgene
            Publicly Available Stocks
            Selected Drosophila transgenes
            Allele
            Transgene
            Publicly Available Stocks
            RNAi constructs available
            Allele
            Transgene
            Publicly Available Stocks
            Selected Drosophila classical alleles
            Allele
            Allele class
            Mutagen
            Publicly Available Stocks
            References (2)