Abstract
When isolated from all contact with other flies until the opportunity to exercise mating choices, Drosophila pseudoobscura displays genetically-mediated compensatory behavior: heterokaryotypic females are more vulnerable than homokaryotes to wholly restricted contact with conspecifics. They are less able to demonstrate normal frequency-dependent sexual selection after isolation than their own homokaryotypes. However, the later the isolation in this holometabolous insect--eggs, first instars, second instars, third instars, pupae, imagoes--the fewer the behavioral effects of this isolation.