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Reference
Citation
Kasai, Y., Nambu, J.R., Lieberman, P.M., Crews, S.T. (1992). Dorsal-ventral patterning in Drosophila: DNA binding of snail protein to the single-minded gene.  Proc. Natl. Acad. Sci. U.S.A. 89(): 3414--3418.
FlyBase ID
FBrf0057526
Publication Type
Research paper
Abstract

The Drosophila snail gene is required for proper mesodermal development. Genetic studies suggest that it functions by repressing adjacent ectodermal gene expression including that of the single-minded (sim) gene. The snail gene encodes a protein with a zinc-finger motif, and here we report that the snail gene product is a sequence-specific DNA binding protein. The snail protein recognizes a 14-base-pair consensus sequence that is found nine times in a 2.8-kilobase sim regulatory region. These results provide evidence for the direct control of sim transcription by snail.

PubMed ID
PubMed Central ID
PMC48878 (PMC) (EuropePMC)
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Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Proc. Natl. Acad. Sci. U.S.A.
    Title
    Proceedings of the National Academy of Sciences of the United States of America
    Publication Year
    1915-
    ISBN/ISSN
    0027-8424
    Data From Reference
    Alleles (2)
    Genes (3)
    Sequence Features (7)
    Experimental Tools (1)
    Transgenic Constructs (1)
    Transcripts (1)