Subject: Helping FlyBase: ADRC-10378 and 10369
Dear Kevin,
Congrats! your computer is plugged in again. What is more it is that
time of the year when I get to bug you about your abstracts!
We are currently curating the abstracts for the upcoming 43rd
(San Diego) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
'Mkph, where the Notch pathway meets Egfr pathway in Drosophila eye
development.'
and
'Egfr, Notch and MAP kinase in the developing eye: a tale of two signals.'
You mention a gene called Mkph in the first, and I'm wondering if it
the same Mkph that we already know about \- FBgn0041200. If not, or if
you cannot say, then I should make a separate gene record for it. You
may know which CG it corresponds to \- and if you could tell me which it
is then that would be great. All the CGs have corresponding gene
records in FlyBase already and we don't like to make duplicate records
for what is actually the same gene unless we can't avoid it.
The second abstract discusses a MAP kinase phosphatase you refer to as
Mkp1 and Mkp-1. It seem very likely that this is exactly the same gene
as Mkph and you are going to have to settle on a single symbol for it.
If you are not sure about the identity of your Mkph with our Mkph then
might I suggest that you choose to go with either Mkp1 or Mkp-1?
Please advise!!
Thank you very much for your help,
all the best,
Rachel.
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Rachel Drysdale, Ph.D.
FlyBase (Cambridge),
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Subject: Re: Helping FlyBase: ADRC-10378 and 10369
Mkph is the one you know and love. Mkp1 is a human homolog.
Note: Mkph is identical by DNA sequence to slingshot (ssh), both of
which are separately listed in polytene region 96B on FlyBase!
They are in different places on Gadfly!
Amazing!
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Regards, Kevin
Kevin Moses
Department of Cell Biology
Emory University School of Medicine
615 Michael Street
Atlanta, GA 30322-3030