Subject: Helping FlyBase: ADRC-10784
Hi Bruce,
How are you? Well I hope \- hope you don't mind this query. We send out
100 such every meeting, mostly asking a similar question...
We are currently curating the abstracts for the upcoming 45th
(Washington DC) Annual Drosophila Research Conference, for FlyBase.
I am writing in connection with your abstract:
Basigin and integrin in Drosophila extra-embryonic membranes promote
morphogenetic cell-cell interactions and prevent anoikis.
You mention a gene symbol that is new to FlyBase, Basigin. Do you know
which of the Genome Project CG annotations your gene corresponds to?
All the CGs have corresponding gene records in FlyBase already and we
don't like to make duplicate records for what is actually the same gene
unless we can't avoid it. The CG symbol becomes a synonym when an annotation is
named with a more descriptive or functional name.
I notice that another abstract mentions a Basigin, by Kathy Curtin:
Basigin, a metastatic factor in mammals, affects cellular architecture in
Drosophila
Kathy has also been asked for a CG number \- it'll all become clear eventually
whether the two Basigins are in fact the same gene.
With best wishes,
Rachel.
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Rachel Drysdale, Ph.D.
FlyBase (Cambridge),
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Subject: Re: Helping FlyBase: ADRC-10784
Rachel,
...
See below for details on what we are calling the Drosophila basigin gene
(it's a well characterized glycoprotein in mammals that, among other
things, is expressed at high levels on the surface of tumors and is thought
to be associated with invasivness).
...
Bruce
>You mention a gene symbol that is new to FlyBase, Basigin. Do you know
>which of the Genome Project CG annotations your gene corresponds to?
Yes: CG31605
There is a male sterile reported to be a mutation in CG31605 called gelded.
There is, however, some conflicting complementation data concerning the
gelded locus and mutations in CG31605. These data indicate complex
complementation, which is a likely scenerio given that CG31605 is
predicted by Gadfly to produce nine different transcripts and two different
proteins. We haven't really sorted out this complex complementation
AS I mentioned above, we have a paper in press in Current Biology \- our
supplementary information includes RT-PCR data showing that the PTT
insertion G289 forms a hybrid RNA with CG31605. We have also shown that
the enhancer trap line B39.1M2 is inserted in CG31605.