Dear FlyBase In my usual stumbling through the highways and byways of FlyBase I came across the following: We have a lovely gene report at http://flybase.org/reports/FBgn0041762.html for a gene named centrin. The basis of that report is i believe a set of papers that report the staining of fly cells/embryos with an antibody to human Centrin: Bettencourt-Dias et al., 2005, Curr. Biol. 15(24): 2199--2207 SAK/PLK4 is required for centriole duplication and flagella development. <up>FBrf0189998</up> Bucciarelli et al., 2003, J. Cell Biol. 160(7): 993--999 Spindle assembly and cytokinesis in the absence of chromosomes during Drosophila male meiosis. <up>FBrf0159033</up> Riparbelli et al., 2002, J. Cell Sci. 115(5): 913--922 A requirement for the Abnormal Spindle protein to organise microtubules of the central spindle for cytokinesis in Drosophila. <up>FBrf0144956</up> de Carcer et al., 2001, EMBO J. 20(11): 2878--2884 Requirement of Hsp90 for centrosomal function reflects its regulation of Polo kinase stability. <up>FBrf0136861</up> Callaini et al., 1999, Biol. Cell 91: 355--366 Centrosome inheritance in insects: Fertilization and parthenogenesis. <up>FBrf0129225</up> Further perusal of other gene reports by somewhat tortured paths that I won't bore you with leads me to CG17493 (http://flybase.org/reports/FBgn0040010.html) In this report under Molecular function one finds: "inferred from sequence or structural similarity with mouse Cetn2" and under orthologs: "ENSP00000359300 Homo sapiens (human)", which is linked to the Human CENT2-001 Ensembl report. Based on BLAST and protein alignments I'm pretty sure this is the Fly ortholog of centrin encoding the fly version of Centrin. Vertebrates having 2 genes our beloved fly only one. I propose that either the two reports be merged or that they point to one another. -- Thom Kaufman