Dmel\CG10672 gene is ortholog of vertebrate DHRS4 genes, human included (supplementary paragraph of Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes, Gabrielli F, Tofanelli S., Gene. 2012 Dec 15; 511(2): 461-9). Vertebrate DHRS4 genes code for Short-Chain dicarbonyl reductase enzymes. (T. Matsunaga et al. Arch Biochem Biophys. 2008 Sep 15;477(2):339-47 and references included in.)
Dmel\CG10672 gene codes for a protein having 44.2% of sequence identity with human DHRS4 enzyme, which has typical DHRS4 molecular characteristics: Rossman fold consensus (AxxxGxG), 25 amino acids interacting with the NADP coenzyme, the three catalytic amino acids, two highly conserved amino acids in vertebrate DHRS4 enzymes and similar Peroxisomal Targeting consensus.
Protein sequence identity may not sufficient to establish homologies between proteins especially when they belong to the same family and to evolutionally distant species (Irimia, M.I., Roy, S.W., 2008. Spliceosomal introns as tools for genomic and evolutionary analysis. Nucleic Acids Res. 36, 1703–1712 and Tress, M.L., et al., 2008. Determination and validation of principal gene products. Bioinformatics 24, 11–17).
Dmel\CG10672 gene has two splicing sites and related phases identical to vertebrates DHRS4 genes (see the above indicated Gene article and supplementary material) and it confirms that D. melanogaster DHRS4 gene is ortholog of vertebrate ones.
With my best regard, Franco Gabrielli