FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Reference Report
Open Close
Reference
Citation
Cuboni, S., Hausch, F. (2014). Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins.  Angew. Chem. Int. Ed. Engl. 53(20): 5008--5009.
FlyBase ID
FBrf0224942
Publication Type
Note
Abstract
In the sweet spot: Cocrystal structures of engineered neurotransmitter transporters reveal the binding mode of commonly prescribed antidepressants, providing a basis for a rational drug design for this class of proteins. The picture shows the structure of the dopamine transporter of Drosophila melanogaster in complex with the antidepressant nortriptyline.
PubMed ID
24729171
PubMed Central ID
DOI
10.1002/anie.201310567
Related Publication(s)
Research paper

X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Penmatsa et al., 2013, Nature 503(7474): 85--90 [FBrf0223218]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    Angew. Chem. Int. Ed. Engl.
    Title
    Angewandte Chemie (International ed. in English)
    ISBN/ISSN
    1433-7851 1521-3773
    Data From Reference